Research workbench
AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing family M member 2 (Q8IWE5)
Analyse AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q8IWE5
- Type
- protein
- Length
- 1,019 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x944f0A419Cb6d1485085105cB3499d49E5BF991A
- Molecule
- Pleckstrin homology domain-containing family M member 2
- UniProt
- Q8IWE5
- Pockets
- 8 · best druggability 0.79
Structure
1 distinct chain · 22% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pleckstrin homology domain-containing family M member 2 | protein | 1019 | 22% helix, 15% strand | Q8IWE5 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 971 | 0.79 | 0.81 | 92 | empty |
| 2 | 517 | 0.61 | 0.74 | 42 | empty |
| 3 | 278 | 0.58 | 0.78 | 26 | empty |
| 4 | 197 | 0.58 | 0.80 | 33 | empty |
| 5 | 360 | 0.57 | 0.75 | 39 | empty |
Compared structures
- 8JCA · Cyrstal structure of SKIP RUN domain in complex with GTP-bound Arl8b(Q75L) · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 3HW2 · Crystal structure of the SifA-SKIP(PH) complex · an experimental structure of the same protein · chain A against B, TM-score 0.10
- 3HW2 · Crystal structure of the sifa-SKIP(PH) complex · an experimental structure of the same protein · chain A against B, TM-score 0.10
- 3CXB · Crystal Structure of sifa and skip · an experimental structure of the same protein · chain A against B, TM-score 0.10
- 3CXB · Crystal structure of sifa and skip · an experimental structure of the same protein · chain A against B, TM-score 0.10
- 3ZFW · Crystal structure of the tpr domain of kinesin light chain 2 in complex with a… · an experimental structure of the same protein · chain A against Y, TM-score 0.01
- 3ZFW · Crystal structure of the TPR domain of kinesin light chain 2 in complex with a… · an experimental structure of the same protein · chain A against Y, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IWE5
- Elsewhere: UniProt Q8IWE5 · AlphaFold DB Q8IWE5
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