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AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P22777)

Analyse AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P22777) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: P22777
Type: protein
Length: 402 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
Molecule: Plasminogen activator inhibitor 1
UniProt: P22777
Pockets: 3 · best druggability 0.58

Structure

1 distinct chain · 28% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasminogen activator inhibitor 1	protein	402	28% helix, 29% strand	P22777

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	185	0.58	0.81	27	empty
2	65	0.41	0.81	14	empty
3	56	0.31	0.76	15	empty

Compared structures

3LW2 · Mouse Plasminogen Activator Inhibitor-1 (PAI-1) · an experimental structure of the same protein · chain A against A, TM-score 0.82
3LW2 · Mouse plasminogen activator inhibitor-1 (pai-1) · an experimental structure of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22777
Elsewhere: UniProt P22777 · AlphaFold DB P22777

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