Research workbench
AlphaFold monomer V2.0 prediction for sialidase-2 (Q9Y3R4)
Analyse AlphaFold monomer V2.0 prediction for sialidase-2 (Q9Y3R4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9Y3R4
- Type
- protein
- Length
- 380 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x114a0357b11cFf6EBe7075749Ec3390CD780d178
- Molecule
- Sialidase-2
- UniProt
- Q9Y3R4
- Pockets
- 2 · best druggability 0.64
Structure
1 distinct chain · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sialidase-2 | protein | 380 | 8% helix, 50% strand | Q9Y3R4 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 305 | 0.64 | 0.80 | 30 | empty |
| 2 | 199 | 0.61 | 0.82 | 30 | empty |
Compared structures
- 2F27 · Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with… · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 2F27 · Crystal structure of the human sialidase NEU2 E111Q-Q112E double mutant in complex with… · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 2F25 · Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.98
- 2F25 · Crystal structure of the human sialidase NEU2 E111Q mutant in complex with dana inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.98
- 1VCU · Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 1VCU · Structure of the human cytosolic sialidase NEU2 in complex with the inhibitor dana · an experimental structure of the same protein · chain A against B, TM-score 0.98
- 2F29 · Crystal structure of the human sialidase NEU2 Q116E mutant in complex with dana inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 2F29 · Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3R4
- Elsewhere: UniProt Q9Y3R4 · AlphaFold DB Q9Y3R4
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