Research workbench
AlphaFold monomer V2.0 prediction for ATP-dependent lipid a-core flippase (P60752)
Analyse AlphaFold monomer V2.0 prediction for ATP-dependent lipid a-core flippase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P60752
- Type
- protein
- Length
- 582 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x774582E07a40A87E4c6afEFD04C85A974BBd781F
- Molecule
- ATP-dependent lipid a-core flippase
- UniProt
- P60752
- Pockets
- 5 · best druggability 0.61
Structure
1 distinct chain · 66% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent lipid a-core flippase | protein | 582 | 66% helix, 10% strand | P60752 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.61 | 0.85 | 23 | empty |
| 2 | 398 | 0.60 | 0.76 | 37 | empty |
| 3 | 218 | 0.53 | 0.76 | 19 | empty |
| 4 | 72 | 0.41 | 0.80 | 16 | empty |
| 5 | 54 | 0.31 | 0.76 | 13 | empty |
Compared structures
- 7PH2 · Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position A60C · an experimental structure of the same protein · chain A against B, TM-score 0.89
- 7PH2 · Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position A60C · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 3B5W · Crystal Structure of Eschericia coli MsbA · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 3B5W · Crystal structure of eschericia COLI msba · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 7PH4 · AMP-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position T68C · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7PH4 · AMP-PNP bound nanodisc reconstituted MsbA with nanobodies, spin-labeled at position T68C · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7PH3 · AMP-PNP bound nanodisc reconstituted MsbA with nanobodies, spin-labeled at position A60C · an experimental structure of the same protein · chain A against B, TM-score 0.71
- 7PH3 · AMP-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position A60C · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7BCW · Structure of MsbA in Salipro with ADP vanadate · an experimental structure of the same protein · chain A against B, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60752
- Elsewhere: UniProt P60752 · AlphaFold DB P60752
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