Research workbench
AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 1 (Q02750)
Analyse AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q02750
- Type
- protein
- Length
- 393 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xDa30399E955a842042B4DfB2a86B9Aff5E5aB0e8
- Molecule
- Dual specificity mitogen-activated protein kinase kinase 1
- UniProt
- Q02750
- Pockets
- 6 · best druggability 0.77
Structure
1 distinct chain · 43% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity mitogen-activated protein kinase kinase 1 | protein | 393 | 43% helix, 12% strand | Q02750 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.77 | 0.81 | 76 | empty |
| 2 | 237 | 0.67 | 0.84 | 26 | empty |
| 3 | 456 | 0.66 | 0.78 | 54 | empty |
| 4 | 123 | 0.46 | 0.78 | 16 | empty |
| 5 | 125 | 0.46 | 0.78 | 17 | empty |
Compared structures
- 9AY7 · Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF · an experimental structure of the same protein · chain A against B, TM-score 0.81
- 3EQD · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQD · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQI · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQI · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3ZLS · Crystal structure of MEK1 in complex with fragment 6 · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3ZLS · Crystal structure of MEK1 in complex with fragment 6 · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQH · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQH · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQG · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3EQG · X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 5BX0 · An automated microscale thermophoresis screening approach for fragment-based lead… · an experimental structure of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02750
- Elsewhere: UniProt Q02750 · AlphaFold DB Q02750
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.