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AlphaFold monomer V2.0 prediction for 2-succinylbenzoate--CoA ligase (P37353)

Analyse AlphaFold monomer V2.0 prediction for 2-succinylbenzoate--CoA ligase (P37353) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: P37353
Type: protein
Length: 451 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x7c75F0f7d6d136A2b8D4C6C6e9b3D8a697949DF1
Molecule: 2-succinylbenzoate--CoA ligase
UniProt: P37353
Pockets: 2 · best druggability 0.85

Structure

1 distinct chain · 27% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2-succinylbenzoate--CoA ligase	protein	451	27% helix, 30% strand	P37353

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1112	0.85	0.86	103	empty
2	73	0.39	0.78	12	empty

Compared structures

5C5H · R195K E. COLI mene with bound osb-ams · an experimental structure of the same protein · chain A against B, TM-score 0.99
5C5H · R195K E. coli MenE with bound OSB-AMS · an experimental structure of the same protein · chain A against B, TM-score 0.99
6NJ0 · Wild-type E. COLI mene with bound M phenylether-linked analogue of osb-ams · an experimental structure of the same protein · chain A against A, TM-score 0.87
6NJ0 · Wild-type E. coli MenE with bound m phenylether-linked analogue of OSB-AMS · an experimental structure of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37353
Elsewhere: UniProt P37353 · AlphaFold DB P37353

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