Research workbench
AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-alpha regulatory subunit (P12367)
Analyse AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P12367
- Type
- protein
- Length
- 401 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf82721010A87D54712b6c5deC75cb63B8BF88c23
- Molecule
- Camp-dependent protein kinase type II-alpha regulatory subunit
- UniProt
- P12367
- Pockets
- 3 · best druggability 0.55
Structure
1 distinct chain · 30% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase type II-alpha regulatory subunit | protein | 401 | 30% helix, 23% strand | P12367 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 253 | 0.55 | 0.77 | 32 | empty |
| 2 | 168 | 0.53 | 0.79 | 26 | empty |
| 3 | 71 | 0.33 | 0.75 | 15 | empty |
Compared structures
- 2QVS · Crystal structure of type iia holoenzyme of camp-dependent protein kinase · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 2QVS · Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 1R2A · The molecular basis for protein kinase a anchoring revealed by solution NMR · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 1R2A · The molecular basis for protein kinase a anchoring revealed by solution NMR · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 1L6E · Solution structure of the docking and dimerization domain of protein kinase A II-alpha… · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 1L6E · Solution structure of the docking and dimerization domain of protein kinase a II-alpha… · an experimental structure of the same protein · chain A against A, TM-score 0.10
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12367
- Elsewhere: UniProt P12367 · AlphaFold DB P12367
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