Research workbench
AlphaFold monomer V2.0 prediction for integrin alpha-1 (P56199)
Analyse AlphaFold monomer V2.0 prediction for integrin alpha-1 (P56199) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P56199
- Type
- protein
- Length
- 1,179 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Integrin alpha-1
- UniProt
- P56199
- Pockets
- 10 · best druggability 0.79
Structure
1 distinct chain · 14% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin alpha-1 | protein | 1179 | 14% helix, 41% strand | P56199 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 918 | 0.79 | 0.81 | 67 | empty |
| 2 | 169 | 0.54 | 0.79 | 33 | empty |
| 3 | 69 | 0.50 | 0.85 | 23 | empty |
| 4 | 157 | 0.45 | 0.76 | 27 | empty |
| 5 | 88 | 0.44 | 0.79 | 15 | empty |
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 1PT6 · I domain from human integrin alpha1-beta1 · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 1PT6 · I domain from human integrin ALPHA1-BETA1 · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 5HGJ · Structure of integrin alpha1beta1 and alpha2beta1 I-domains explain differential… · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 5HGJ · Structure of integrin ALPHA1BETA1 and ALPHA2BETA1 I-domains explain differential… · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 1QCY · The crystal structure of the I-domain of human integrin ALPHA1BETA1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 1QCY · The crystal structure of the I-domain of human integrin ALPHA1BETA1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 1QC5 · I domain from integrin ALPHA1-BETA1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 1QC5 · I Domain from Integrin Alpha1-Beta1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56199
- Elsewhere: UniProt P56199 · AlphaFold DB P56199
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