Research workbench
AlphaFold monomer V2.0 prediction for interleukin-12 receptor subunit beta-1 (Q60837)
Analyse AlphaFold monomer V2.0 prediction for interleukin-12 receptor subunit beta-1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q60837
- Type
- protein
- Length
- 738 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Interleukin-12 receptor subunit beta-1
- UniProt
- Q60837
- Pockets
- 7 · best druggability 0.52
Structure
1 distinct chain · 7% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-12 receptor subunit beta-1 | protein | 738 | 7% helix, 34% strand | Q60837 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.52 | 0.79 | 30 | empty |
| 2 | 185 | 0.47 | 0.75 | 24 | empty |
| 3 | 122 | 0.45 | 0.78 | 19 | empty |
| 4 | 89 | 0.43 | 0.79 | 17 | empty |
| 5 | 76 | 0.38 | 0.78 | 17 | empty |
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 8ODZ · Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling… · an experimental structure of the same protein · chain A against C, TM-score 0.59
- 8OE0 · Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling… · an experimental structure of the same protein · chain A against C, TM-score 0.56
- 8PB1 · Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling… · an experimental structure of the same protein · chain A against C, TM-score 0.25
- 8CR5 · Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta. · an experimental structure of the same protein · chain A against B, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60837
- Elsewhere: UniProt Q60837 · AlphaFold DB Q60837
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