Research workbench
AlphaFold monomer V2.0 prediction for RAS guanyl-releasing protein 1 (O95267)
Analyse AlphaFold monomer V2.0 prediction for RAS guanyl-releasing protein 1 (O95267) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O95267
- Type
- protein
- Length
- 797 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9Ea1c8D4c1A5bDE0a3a9E14459F06eb4dcf9FEf1
- Molecule
- RAS guanyl-releasing protein 1
- UniProt
- O95267
- Pockets
- 8 · best druggability 0.76
Structure
1 distinct chain · 48% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS guanyl-releasing protein 1 | protein | 797 | 48% helix, 5% strand | O95267 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.76 | 0.79 | 88 | empty |
| 2 | 341 | 0.66 | 0.80 | 32 | empty |
| 3 | 468 | 0.63 | 0.76 | 45 | empty |
| 4 | 365 | 0.55 | 0.74 | 36 | empty |
| 5 | 235 | 0.54 | 0.77 | 32 | empty |
Compared structures
- 4L9M · Autoinhibited state of the Ras-specific exchange factor RasGRP1 · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 4L9M · Autoinhibited state of the RAS-specific exchange factor RASGRP1 · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 4L9U · Structure of C-terminal coiled coil of RasGRP1 · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 4L9U · Structure of C-terminal coiled coil of RASGRP1 · an experimental structure of the same protein · chain A against A, TM-score 0.05
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95267
- Elsewhere: UniProt O95267 · AlphaFold DB O95267
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