Research workbench
AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein subunit alpha-12 (P27600)
Analyse AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P27600
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb17F0b89Fb447a3F06B40871336A733435186471
- Molecule
- Guanine nucleotide-binding protein subunit alpha-12
- UniProt
- P27600
- Pockets
- 3 · best druggability 0.75
Structure
1 distinct chain · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein subunit alpha-12 | protein | 379 | 53% helix, 11% strand | P27600 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 508 | 0.75 | 0.83 | 58 | empty |
| 2 | 187 | 0.60 | 0.82 | 24 | empty |
| 3 | 203 | 0.48 | 0.75 | 29 | empty |
Compared structures
- 1ZCA · Crystal structure of G alpha 12 in complex with GDP, Mg2+ and AlF4- · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 1ZCA · Crystal structure of G alpha 12 in complex with GDP, MG2+ and ALF4- · an experimental structure of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27600
- Elsewhere: UniProt P27600 · AlphaFold DB P27600
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