Research workbench
AlphaFold monomer V2.0 prediction for RAS guanine nucleotide exchange factor O (Q8IS11)
Analyse AlphaFold monomer V2.0 prediction for RAS guanine nucleotide exchange factor O… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q8IS11
- Type
- protein
- Length
- 944 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x109960bCAd650b4CBba1259a959355c840B45334
- Molecule
- RAS guanine nucleotide exchange factor O
- UniProt
- Q8IS11
- Pockets
- 8 · best druggability 0.68
Structure
1 distinct chain · 45% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS guanine nucleotide exchange factor O | protein | 944 | 45% helix, 6% strand | Q8IS11 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 803 | 0.68 | 0.74 | 66 | empty |
| 2 | 456 | 0.63 | 0.77 | 42 | empty |
| 3 | 367 | 0.58 | 0.75 | 30 | empty |
| 4 | 112 | 0.46 | 0.79 | 19 | empty |
| 5 | 64 | 0.31 | 0.75 | 14 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IS11
- Elsewhere: UniProt Q8IS11 · AlphaFold DB Q8IS11
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