Research workbench
AlphaFold monomer V2.0 prediction for alpha-fetoprotein (P02771)
Analyse AlphaFold monomer V2.0 prediction for alpha-fetoprotein (P02771) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P02771
- Type
- protein
- Length
- 609 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Alpha-fetoprotein
- UniProt
- P02771
- Pockets
- 10 · best druggability 0.82
Structure
1 distinct chain · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-fetoprotein | protein | 609 | 69% helix, 0% strand | P02771 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1133 | 0.82 | 0.83 | 97 | empty |
| 2 | 257 | 0.70 | 0.85 | 36 | empty |
| 3 | 181 | 0.65 | 0.85 | 24 | empty |
| 4 | 186 | 0.54 | 0.78 | 19 | empty |
| 5 | 189 | 0.47 | 0.75 | 26 | empty |
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 7YIM · Cryo-EM structure of human Alpha-fetoprotein · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 8X1N · Cryo-EM structure of human alpha-fetoprotein · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 3MRK · Crystal Structure of MHC class I HLA-A2 molecule complexed with AFP137 nonapeptide · an experimental structure of the same protein · chain A against P, TM-score 0.01
- 3MRK · Crystal structure of MHC class I HLA-A2 molecule complexed with AFP137 nonapeptide · an experimental structure of the same protein · chain A against P, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02771
- Elsewhere: UniProt P02771 · AlphaFold DB P02771
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