Research workbench
AlphaFold monomer V2.0 prediction for ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family member 2 (Q9R1E6)
Analyse AlphaFold monomer V2.0 prediction for ectonucleotide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9R1E6
- Type
- protein
- Length
- 862 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x92138789186f6f4Bce7a1e4346cf9ae15fdFBBBf
- Molecule
- Ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family member 2
- UniProt
- Q9R1E6
- Pockets
- 14 · best druggability 0.84
Structure
1 distinct chain · 28% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family member 2 | protein | 862 | 28% helix, 17% strand | Q9R1E6 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.84 | 0.84 | 77 | empty |
| 2 | 221 | 0.58 | 0.80 | 32 | empty |
| 3 | 245 | 0.58 | 0.79 | 30 | empty |
| 4 | 183 | 0.55 | 0.79 | 26 | empty |
| 5 | 239 | 0.53 | 0.76 | 43 | empty |
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 3NKM · Crystal structure of mouse autotaxin · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 3NKM · Crystal structure of mouse autotaxin · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 5LIA · Crystal structure of murine autotaxin in complex with a small molecule inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 5LIA · Crystal structure of murine autotaxin in complex with a small molecule inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 3WAV · Crystal structure of autotaxin in complex with compound 10 · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 3WAV · Crystal Structure of Autotaxin in Complex with Compound 10 · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 3WAX · Crystal structure of autotaxin in complex with 3BOA · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 3WAX · Crystal Structure of Autotaxin in Complex with 3BoA · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 3NKP · Crystal structure of mouse autotaxin in complex with 18:1-lpa · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 3NKP · Crystal structure of mouse autotaxin in complex with 18:1-LPA · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 3WAY · Crystal structure of autotaxin in complex with 4BOA · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 3WAY · Crystal Structure of Autotaxin in Complex with 4BoA · an experimental structure of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9R1E6
- Elsewhere: UniProt Q9R1E6 · AlphaFold DB Q9R1E6
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