Research workbench
AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EHMT1 (Q9H9B1)
Analyse AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EHMT1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9H9B1
- Type
- protein
- Length
- 1,298 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7a1388B6Aad67B04634A32f63b8A6D6005eab86c
- Molecule
- Histone-lysine N-methyltransferase EHMT1
- UniProt
- Q9H9B1
- Pockets
- 12 · best druggability 0.68
Structure
1 distinct chain · 17% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase EHMT1 | protein | 1298 | 17% helix, 9% strand | Q9H9B1 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 482 | 0.68 | 0.79 | 53 | empty |
| 2 | 408 | 0.61 | 0.76 | 36 | empty |
| 3 | 132 | 0.53 | 0.81 | 21 | empty |
| 4 | 215 | 0.53 | 0.77 | 33 | empty |
| 5 | 236 | 0.49 | 0.75 | 26 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6BY9 · Crystal structure of EHMT1 · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 6BY9 · Crystal structure of EHMT1 · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 3HNA · Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in… · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 3HNA · Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in… · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 7T7M · Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1) · an experimental structure of the same protein · chain A against D, TM-score 0.20
- 7T7M · Structure of human glp set-domain (EHMT1) in complex with covalent inhibitor (compound 1) · an experimental structure of the same protein · chain A against D, TM-score 0.20
- 6MBP · GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 6MBP · Glp methyltransferase with inhibitor EML741- P3121 crystal form · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 6MBO · Glp methyltransferase with inhibitor EML741-P212121 crystal form · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 6MBO · GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 3SW9 · Glp (G9A-like protein) set domain in complex with DNMT3AK44ME0 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 3SW9 · GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H9B1
- Elsewhere: UniProt Q9H9B1 · AlphaFold DB Q9H9B1
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