UniProt Q9Y6M5
Proton-coupled zinc antiporter SLC30A1 (Q9Y6M5)
Proton-coupled zinc antiporter SLC30A1 (UniProt Q9Y6M5): 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 75 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y6M5
- Protein
- Proton-coupled zinc antiporter SLC30A1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 75 · 8 records with a druggable one
Structures
8 records of Q9Y6M5 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8J2G | Human ZnT1-D47N/D255N mutant | electron microscopy | A, B | — | 11 (best 0.86) |
| 8XM6 | Cryo-EM structure of human ZnT1 WT, in the absence of zinc, determined in an outward-facing… | electron microscopy | B, A | ZN, AV0, Y01 | 12 (best 0.87) |
| 8XMA | Cryo-EM structure of human ZnT1 WT, in the presence of zinc, determined in an outward-facing… | electron microscopy | B, A | ZN, AV0, Y01 | 9 (best 0.79) |
| 8XMF | Cryo-EM structure of human ZnT1 WT at a low PH, in the presence of zinc, determined in an… | electron microscopy | B, A | ZN, AV0, Y01 | 8 (best 0.73) |
| 8XMJ | Cryo-EM structure of human ZnT1 WT, in the presence of zinc, determined in heterogeneous… | electron microscopy | B, A | ZN, AV0, Y01 | 11 (best 0.84) |
| 8ZSB | Cryo-EM structure of human ZnT1, in the absence of zinc, determined in outward-facing conformation | electron microscopy | A, B | ZN | 9 (best 0.81) |
| 8ZSZ | Cryo-EM structure of human ZnT1, in the presence of zinc, determined in outward-facing conformation | electron microscopy | A, B | ZN | 11 (best 0.87) |
| Q9Y6M5 | AlphaFold monomer V2.0 prediction for zinc transporter 1 (Q9Y6M5) | predicted | A | — | 4 (best 0.78) |
Ligands
Experiment against prediction
- 8XMF chain A against the predicted model Q9Y6M5: TM-score 0.85, RMSD 2.53 Å
- 8XMF chain B against the predicted model Q9Y6M5: TM-score 0.84, RMSD 2.67 Å
- 8XMJ chain A against the predicted model Q9Y6M5: TM-score 0.84, RMSD 2.91 Å
- 8ZSB chain A against the predicted model Q9Y6M5: TM-score 0.82, RMSD 3.14 Å
- 8ZSB chain B against the predicted model Q9Y6M5: TM-score 0.82, RMSD 3.15 Å
- 8ZSZ chain B against the predicted model Q9Y6M5: TM-score 0.81, RMSD 3.52 Å
- 8ZSZ chain A against the predicted model Q9Y6M5: TM-score 0.81, RMSD 3.51 Å
- 8XM6 chain B against the predicted model Q9Y6M5: TM-score 0.79, RMSD 3.36 Å
- 8J2G chain A against the predicted model Q9Y6M5: TM-score 0.79, RMSD 3.81 Å
- 8J2G chain B against the predicted model Q9Y6M5: TM-score 0.79, RMSD 3.81 Å
Elsewhere
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