UniProt Q9Y5P4
Lipid-transfer protein cert (Q9Y5P4)
Lipid-transfer protein cert (UniProt Q9Y5P4): 24 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y5P4
- Protein
- Lipid-transfer protein cert
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 12 · 4 records with a druggable one
Structures
25 records of Q9Y5P4 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RSG | Solution structure of the CERT PH domain | solution nmr | A | — | — |
| 2RSG | Solution structure of the cert pH domain | solution nmr | A | — | — |
| 4HHV | Crystal structure of ceramide transfer protein pleckstrin homology domain | x-ray diffraction | A, B | — | — |
| 4HHV | Crystal structure of ceramide transfer protein pleckstrin homology domain | x-ray diffraction | A, B | — | — |
| 5JJD | crystal structure of the ceramide transfer protein PH and START domain complex | x-ray diffraction | A, B | — | — |
| 5JJD | Crystal structure of the ceramide transfer protein pH and start domain complex | x-ray diffraction | A, B | — | — |
| 5ZYG | Crystal structure of cert start domain in complex with compound B5 | x-ray diffraction | A | 9N3 | — |
| 5ZYH | Crystal structure of CERT START domain in complex with compound E5 | x-ray diffraction | A | 9N0 | 3 (best 0.84) |
| 5ZYH | Crystal structure of cert start domain in complex with compound E5 | x-ray diffraction | A | 9N0 | — |
| 5ZYI | Crystal structure of cert start domain in complex with compound E16 | x-ray diffraction | A | 9ML | — |
| 5ZYJ | Crystal structure of cert start domain in complex with compound E16A | x-ray diffraction | A | 9ML | — |
| 5ZYK | Crystal structure of CERT START domain in complex with compound E25 | x-ray diffraction | A | 9MC | 3 (best 0.85) |
| 5ZYK | Crystal structure of cert start domain in complex with compound E25 | x-ray diffraction | A | 9MC | — |
| 5ZYL | Crystal structure of CERT START domain in complex with compound E25A | x-ray diffraction | A | 9MC | — |
| 5ZYL | Crystal structure of cert start domain in complex with compound E25A | x-ray diffraction | A | 9MC | — |
| 5ZYM | Crystal structure of CERT START domain in complex with compound E25B | x-ray diffraction | A | 9M6 | 3 (best 0.85) |
| 5ZYM | Crystal structure of cert start domain in complex with compound E25B | x-ray diffraction | A | 9M6 | — |
| 6IEZ | Crystal structure of cert start domain in complex with compound B16 | x-ray diffraction | A | A50 | — |
| 6IF0 | Crystal structure of CERT START domain in complex with compound D16 | x-ray diffraction | A | A59 | — |
| 6IF0 | Crystal structure of cert start domain in complex with compound D16 | x-ray diffraction | A | A59 | — |
| 6J0O | Crystal structure of CERT START domain in complex with compound SC1 | x-ray diffraction | A | XAF, UNX | — |
| 6J0O | Crystal structure of cert start domain in complex with compound SC1 | x-ray diffraction | A | XAF, UNX | — |
| 6J81 | Crystal structure of CERT START domain in complex with compound E14 | x-ray diffraction | A | B8X | 3 (best 0.85) |
| 6J81 | Crystal structure of cert start domain in complex with compound E14 | x-ray diffraction | A | B8X | — |
| Q9Y5P4 | AlphaFold monomer V2.0 prediction for ceramide transfer protein (Q9Y5P4) | predicted | A | — | — |
Ligands
- 9MC · 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol · in 4 records
- 9M6 · 2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol · in 2 records
- 9ML · 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol · in 2 records
- 9N0 · 2-[4-[3-~{tert}-butyl-5-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol · in 2 records
- A59 · 2-({4'-pentyl-3'-[(Z)-2-(pyridin-2-yl)ethenyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol · in 2 records
- B8X · 2-[4-[4-propyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol · in 2 records
- UNX · Unknown atom or ion · in 2 records
- XAF · 2-[4-[2-fluoranyl-5-[3-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]phenyl]phenyl]sulfonylethanol · in 2 records
- 9N3 · 2-[4-[3-~{tert}-butyl-5-(2-pyridin-2-ylethyl) phenyl]phenyl]sulfonylethanol · in 1 record
- A50 · 2-({4'-pentyl-3'-[2-(pyridin-2-yl)ethyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol · in 1 record
Experiment against prediction
- 5ZYK chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.71 Å
- 5ZYK chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.71 Å
- 6J0O chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.71 Å
- 6J0O chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.71 Å
- 6J81 chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.72 Å
- 6J81 chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.72 Å
- 6IEZ chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.73 Å
- 5ZYH chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.74 Å
- 5ZYH chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.74 Å
- 6IF0 chain A against the predicted model Q9Y5P4: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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