UniProt Q9Y2K2
Serine/threonine-protein kinase SIK3 (Q9Y2K2)
Serine/threonine-protein kinase SIK3 (UniProt Q9Y2K2), EC 2.7.11.1: 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Y2K2
- Protein
- Serine/threonine-protein kinase SIK3
- EC
- 2.7.11.1
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 55 · 4 records with a druggable one
Structures
4 records of Q9Y2K2 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8OKU | Salt-Inducible Kinase 3 in complex with an inhibitor | x-ray diffraction | A, B | VRU | 10 (best 0.77) |
| 8R4O | Salt inducible kinase 3 in complex with inhibitor | x-ray diffraction | A, C, E, G, I, K | XVI, SO4 | 20 (best 0.82) |
| 8R4Q | Salt inducible kinase 3 in complex with inhibitor | x-ray diffraction | A, C, E, G, I, K | DB8, SO4 | 20 (best 0.81) |
| Q9Y2K2 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase SIK3 (Q9Y2K2) | predicted | A | — | 5 (best 0.78) |
Ligands
- SO4 · Sulfate ion · in 2 records
- DB8 · 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile · in 1 record
- VRU · ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide · in 1 record
- XVI · 2-[bis(fluoranyl)methoxy]-4-[6-(2-cyanopropan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]-~{N}-[(1~{R},2~{S})-2-fluoranylcyclopropyl]-6-methoxy-benzamide · in 1 record
Experiment against prediction
- 8R4Q chain A against the predicted model Q9Y2K2: TM-score 0.98, RMSD 1.03 Å
- 8R4O chain C against the predicted model Q9Y2K2: TM-score 0.98, RMSD 1.04 Å
- 8R4O chain E against the predicted model Q9Y2K2: TM-score 0.98, RMSD 1.05 Å
- 8R4O chain A against the predicted model Q9Y2K2: TM-score 0.98, RMSD 1.06 Å
- 8R4O chain I against the predicted model Q9Y2K2: TM-score 0.97, RMSD 1.10 Å
- 8R4O chain G against the predicted model Q9Y2K2: TM-score 0.97, RMSD 1.23 Å
- 8R4Q chain G against the predicted model Q9Y2K2: TM-score 0.97, RMSD 1.26 Å
- 8R4Q chain E against the predicted model Q9Y2K2: TM-score 0.97, RMSD 1.23 Å
- 8R4Q chain C against the predicted model Q9Y2K2: TM-score 0.96, RMSD 1.28 Å
- 8R4O chain K against the predicted model Q9Y2K2: TM-score 0.96, RMSD 1.31 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.