UniProt Q9Y2C4
Nuclease EXOG, mitochondrial (Q9Y2C4)
Nuclease EXOG, mitochondrial (UniProt Q9Y2C4), EC 3.1.30.-: 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 71 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9Y2C4
- Protein
- Nuclease EXOG, mitochondrial
- EC
- 3.1.30.-
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 71 · 6 records with a druggable one
Structures
19 records of Q9Y2C4 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4A1N | Human Mitochondrial endo-exonuclease | x-ray diffraction | A | — | — |
| 4A1N | Human mitochondrial endo-exonuclease | x-ray diffraction | A | — | — |
| 5T3V | A novel domain in human exog converts apoptotic endonuclease to DNA- repair enzyme | x-ray diffraction | A, B | MN, SO4 | — |
| 5T40 | A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme | x-ray diffraction | A, B | SO4, MG | 5 (best 0.84) |
| 5T40 | A novel domain in human exog converts apoptotic endonuclease to DNA- repair enzyme | x-ray diffraction | A, B | SO4, MG | — |
| 5T4I | A novel domain in human exog converts apoptotic endonuclease to DNA- repair enzyme | x-ray diffraction | A, B | MN | — |
| 5T5C | A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme | x-ray diffraction | A, B | MG | 9 (best 0.83) |
| 5T5C | A novel domain in human exog converts apoptotic endonuclease to DNA- repair enzyme | x-ray diffraction | A, B | MG | — |
| 5ZKI | Human EXOG-H140A in complex with duplex DNA | x-ray diffraction | A, B | CL, MG | 5 (best 0.83) |
| 5ZKI | Human exog-H140A in complex with duplex DNA | x-ray diffraction | A, B | CL, MG | — |
| 5ZKJ | Human EXOG-H140A in complex with RNA/DNA hybrid duplex | x-ray diffraction | A, B | MG, CL | — |
| 5ZKJ | Human exog-H140A in complex with RNA/DNA hybrid duplex | x-ray diffraction | A, B | MG, CL | — |
| 6IID | Human EXOG-H140A in complex with RNA-DNA chimeric duplex | x-ray diffraction | A, B, C, D | MG | 17 (best 0.85) |
| 6IID | Human exog-H140A in complex with RNA-DNA chimeric duplex | x-ray diffraction | A, B, C, D | MG | — |
| 7R6T | Human EXOG complexed with dRP-containing DNA | x-ray diffraction | D, C, L | MG | 15 (best 0.83) |
| 7R6T | Human exog complexed with drp-containing DNA | x-ray diffraction | D, C, L | MG | — |
| 7R6V | Human EXOG complexed with dRP-containing DNA | x-ray diffraction | D, E, G, I | MG, SO4 | 20 (best 0.86) |
| 7R6V | Human exog complexed with drp-containing DNA | x-ray diffraction | D, E, G, I | MG, SO4 | — |
| Q9Y2C4 | AlphaFold monomer V2.0 prediction for nuclease exog, mitochondrial (Q9Y2C4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5T40 chain A against the predicted model Q9Y2C4: TM-score 1.00, RMSD 0.37 Å
- 5T40 chain A against the predicted model Q9Y2C4: TM-score 1.00, RMSD 0.37 Å
- 5T40 chain B against the predicted model Q9Y2C4: TM-score 1.00, RMSD 0.41 Å
- 5T40 chain B against the predicted model Q9Y2C4: TM-score 1.00, RMSD 0.41 Å
- 5T3V chain B against the predicted model Q9Y2C4: TM-score 1.00, RMSD 0.41 Å
- 5T3V chain A against the predicted model Q9Y2C4: TM-score 0.99, RMSD 0.48 Å
- 5T5C chain B against the predicted model Q9Y2C4: TM-score 0.99, RMSD 0.52 Å
- 5T5C chain B against the predicted model Q9Y2C4: TM-score 0.99, RMSD 0.52 Å
- 5T4I chain B against the predicted model Q9Y2C4: TM-score 0.99, RMSD 0.56 Å
- 5ZKI chain A against the predicted model Q9Y2C4: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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