UniProt Q9V2G1
tRNA (guanine(37)-N1)-methyltransferase Trm5a (Q9V2G1)
tRNA (guanine(37)-N1)-methyltransferase Trm5a (UniProt Q9V2G1), EC 2.1.1.228: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 26 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9V2G1
- Protein
- tRNA (guanine(37)-N1)-methyltransferase Trm5a
- EC
- 2.1.1.228
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 26 · 4 records with a druggable one
Structures
13 records of Q9V2G1 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HJI | Crystal Structure of Pyrococcus abyssi Trm5a complexed with adenosine | x-ray diffraction | A | ADN | 3 (best 0.77) |
| 5HJI | Crystal structure of pyrococcus abyssi TRM5A complexed with adenosine | x-ray diffraction | A | — | — |
| 5HJJ | Crystal Structure of Pyrococcus abyssi Trm5a | x-ray diffraction | A | — | — |
| 5HJJ | Crystal structure of pyrococcus abyssi TRM5A | x-ray diffraction | A | — | — |
| 5HJK | Crystal Structure of Pyrococcus abyssi Trm5a complexed with SAH | x-ray diffraction | A | — | — |
| 5HJK | Crystal structure of pyrococcus abyssi TRM5A complexed with sah | x-ray diffraction | A | — | — |
| 5HJM | Crystal Structure of Pyrococcus abyssi Trm5a complexed with MTA | x-ray diffraction | A | MTA | — |
| 5HJM | Crystal structure of pyrococcus abyssi TRM5A complexed with mta | x-ray diffraction | A | — | — |
| 5WT1 | Pyrococcus abyssi methyltransferase PaTrm5a bound by SAH and cognate tRNA | x-ray diffraction | A, B | SAH | 14 (best 0.77) |
| 5WT1 | Pyrococcus abyssi methyltransferase PATRM5A bound by sah and cognate tRNA | x-ray diffraction | A, B | — | — |
| 5WT3 | Pyrococcus abyssi methyltransferase PaTrm5a bound by MTA and cognate tRNA | x-ray diffraction | A | MTA | 8 (best 0.78) |
| 5WT3 | Pyrococcus abyssi methyltransferase PATRM5A bound by mta and cognate tRNA | x-ray diffraction | A | MTA | — |
| Q9V2G1 | AlphaFold monomer V2.0 prediction for tRNA (GUANINE(37)-N1)/4-DEMETHYLWYOSINE(37)-methyltransferase… | predicted | A | — | 1 (best 0.76) |
Ligands
Experiment against prediction
- 5WT1 chain B against the predicted model Q9V2G1: TM-score 0.95, RMSD 1.64 Å
- 5WT3 chain A against the predicted model Q9V2G1: TM-score 0.94, RMSD 1.70 Å
- 5WT3 chain A against the predicted model Q9V2G1: TM-score 0.94, RMSD 1.70 Å
- 5WT1 chain A against the predicted model Q9V2G1: TM-score 0.94, RMSD 1.70 Å
- 5WT1 chain B against the predicted model Q9V2G1: TM-score 0.94, RMSD 1.64 Å
- 5WT1 chain A against the predicted model Q9V2G1: TM-score 0.94, RMSD 1.70 Å
- 5HJM chain A against the predicted model Q9V2G1: TM-score 0.76, RMSD 1.25 Å
- 5HJM chain A against the predicted model Q9V2G1: TM-score 0.76, RMSD 1.25 Å
- 5HJJ chain A against the predicted model Q9V2G1: TM-score 0.77, RMSD 1.41 Å
- 5HJJ chain A against the predicted model Q9V2G1: TM-score 0.77, RMSD 1.41 Å
Elsewhere
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