UniProt Q9UZY0
N-glycosylase/DNA lyase (Q9UZY0)
N-glycosylase/DNA lyase (UniProt Q9UZY0), EC 3.2.2.-, 4.2.99.18: 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UZY0
- Protein
- N-glycosylase/DNA lyase
- EC
- 3.2.2.-, 4.2.99.18
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 21 · 5 records with a druggable one
Structures
15 records of Q9UZY0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7OLB | Crystal structure of Pab-AGOG, an 8-oxoguanine DNA glycosylase from Pyrococcus abyssi | x-ray diffraction | A | CL, NA | — |
| 7OLB | Crystal structure of pab-agog, an 8-oxoguanine DNA glycosylase from pyrococcus abyssi | x-ray diffraction | A | CL, NA | — |
| 7OLI | Crystal structure of Pab-AGOG in complex with 8-oxoguanosine | x-ray diffraction | A, B | 8HG | 3 (best 0.60) |
| 7OLI | Crystal structure of pab-agog in complex with 8-oxoguanosine | x-ray diffraction | A, B | 8HG | — |
| 7OUE | Crystal structure of a trapped Pab-AGOG/single-standed DNA covalent intermediate | x-ray diffraction | A, C, E, G | PO4, K | 11 (best 0.71) |
| 7OUE | Crystal structure of a trapped pab-AGOG/SINGLE-standed DNA covalent intermediate | x-ray diffraction | A, C, E, G | PO4, K | — |
| 7OY7 | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing… | x-ray diffraction | A | — | 2 (best 0.70) |
| 7OY7 | Crystal structure of a trapped pab-AGOG/DOUBLE-standed DNA covalent intermediate (DNA containing… | x-ray diffraction | A | — | — |
| 7P0W | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing… | x-ray diffraction | A | NA | 2 (best 0.70) |
| 7P0W | Crystal structure of a trapped pab-AGOG/DOUBLE-standed DNA covalent intermediate (DNA containing… | x-ray diffraction | A | NA | — |
| 7P8L | Crystal structure of Pyrococcus abyssi 8-oxoguanine DNA glycosylase (PabAGOG) in complex with dsDNA… | x-ray diffraction | A | — | 1 (best 0.26) |
| 7P8L | Crystal structure of pyrococcus abyssi 8-oxoguanine DNA glycosylase (pabagog) in complex with dsdna… | x-ray diffraction | A | — | — |
| 7P9Z | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing… | x-ray diffraction | A | — | 2 (best 0.63) |
| 7P9Z | Crystal structure of a trapped pab-AGOG/DOUBLE-standed DNA covalent intermediate (DNA containing… | x-ray diffraction | A | — | — |
| Q9UZY0 | AlphaFold monomer V2.0 prediction for N-GLYCOSYLASE/DNA lyase (Q9UZY0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7OLI chain A against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.40 Å
- 7OLI chain A against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.40 Å
- 7P8L chain A against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.41 Å
- 7P8L chain A against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.41 Å
- 7OLI chain B against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.43 Å
- 7OLI chain B against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.43 Å
- 7OLB chain A against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.55 Å
- 7OLB chain A against the predicted model Q9UZY0: TM-score 0.98, RMSD 0.55 Å
- 7P9Z chain A against the predicted model Q9UZY0: TM-score 0.97, RMSD 0.79 Å
- 7P9Z chain A against the predicted model Q9UZY0: TM-score 0.97, RMSD 0.79 Å
Elsewhere
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