UniProt Q9UNA0
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Q9UNA0)
A disintegrin and metalloproteinase with thrombospondin motifs 5 (UniProt Q9UNA0), EC 3.4.24.-: 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9UNA0
- Protein
- A disintegrin and metalloproteinase with thrombospondin motifs 5
- EC
- 3.4.24.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
15 records of Q9UNA0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RJQ | Crystal structure of ADAMTS5 with inhibitor bound | x-ray diffraction | A | — | — |
| 2RJQ | Crystal structure of ADAMTS5 with inhibitor bound | x-ray diffraction | A | — | — |
| 3B8Z | High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2) | x-ray diffraction | A, B | — | — |
| 3B8Z | High resolution crystal structure of the catalytic domain of adamts-5 (aggrecanase-2) | x-ray diffraction | A, B | — | — |
| 3HY7 | Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat | x-ray diffraction | A, B | — | — |
| 3HY7 | Crystal structure of the catalytic domain of adamts-5 in complex with marimastat | x-ray diffraction | A, B | — | — |
| 3HY9 | Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound | x-ray diffraction | A, B | — | — |
| 3HY9 | Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound | x-ray diffraction | A, B | — | — |
| 3HYG | Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound | x-ray diffraction | A, B | — | — |
| 3HYG | Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound | x-ray diffraction | A, B | — | — |
| 3LJT | Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound | x-ray diffraction | A | — | — |
| 3LJT | Crystal structure of the catalytic domain of adamts-5 in complex with an amino-2-indanol compound | x-ray diffraction | A | — | — |
| 6YJM | Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with the Inhibitor GLPG1972 | x-ray diffraction | A, B | ZN, CA, OU5 | 3 (best 0.69) |
| 6YJM | Crystal structure of the catalytic domain of adamts-5 in complex with the inhibitor GLPG1972 | x-ray diffraction | A, B | ZN, CA, OU5 | — |
| Q9UNA0 | AlphaFold monomer V2.0 prediction for a disintegrin and metalloproteinase with thrombospondin… | predicted | A | — | — |
Ligands
Experiment against prediction
- 2RJQ chain A against the predicted model Q9UNA0: TM-score 0.99, RMSD 0.68 Å
- 2RJQ chain A against the predicted model Q9UNA0: TM-score 0.99, RMSD 0.68 Å
- 6YJM chain B against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.82 Å
- 6YJM chain B against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.82 Å
- 6YJM chain A against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.99 Å
- 6YJM chain A against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.99 Å
- 3HY9 chain A against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.97 Å
- 3HY9 chain A against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.97 Å
- 3HYG chain A against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.99 Å
- 3HYG chain A against the predicted model Q9UNA0: TM-score 0.98, RMSD 0.99 Å
Elsewhere
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