UniProt Q9UM47
Neurogenic locus notch homolog protein 3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (UniProt Q9UM47): 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9UM47
- Protein
- Neurogenic locus notch homolog protein 3
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 32 · 4 records with a druggable one
Structures
12 records of Q9UM47 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ZLP | Crystal Structure of Notch3 Negative Regulatory Region | x-ray diffraction | A, B | — | — |
| 4ZLP | Crystal structure of NOTCH3 negative regulatory region | x-ray diffraction | A, B | — | — |
| 5CZV | Crystal structure of Notch3 NRR in complex with 20350 Fab | x-ray diffraction | A | CA, NAG | 3 (best 0.58) |
| 5CZV | Crystal structure of NOTCH3 nrr in complex with 20350 Fab | x-ray diffraction | A | — | — |
| 5CZX | Crystal structure of Notch3 NRR in complex with 20358 Fab | x-ray diffraction | A, B | NAG, CA | 6 (best 0.80) |
| 5CZX | Crystal structure of NOTCH3 nrr in complex with 20358 Fab | x-ray diffraction | A, B | — | — |
| 6WQU | CSL (RBPJ) bound to Notch3 RAM and DNA | x-ray diffraction | D | — | — |
| 6WQU | Csl (rbpj) bound to NOTCH3 ram and DNA | x-ray diffraction | D | — | — |
| 6XSW | Structure of the Notch3 NRR in complex with an antibody Fab Fragment | x-ray diffraction | C, F, J, X | NAG, CA | 13 (best 0.72) |
| 6XSW | Structure of the NOTCH3 nrr in complex with an antibody Fab fragment | x-ray diffraction | C, F, J, X | NAG, CA | — |
| 8OS0 | Solution NMR structure of Notch3 WT TMD | solution nmr | A | — | — |
| Q9UM47 | AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 3 (Q9UM47) | predicted | A | — | 10 (best 0.69) |
Ligands
Experiment against prediction
- 6XSW chain C against the predicted model Q9UM47: TM-score 0.97, RMSD 1.08 Å
- 6XSW chain C against the predicted model Q9UM47: TM-score 0.97, RMSD 1.08 Å
- 4ZLP chain B against the predicted model Q9UM47: TM-score 0.97, RMSD 1.16 Å
- 4ZLP chain B against the predicted model Q9UM47: TM-score 0.97, RMSD 1.16 Å
- 5CZV chain A against the predicted model Q9UM47: TM-score 0.97, RMSD 1.16 Å
- 5CZV chain A against the predicted model Q9UM47: TM-score 0.97, RMSD 1.16 Å
- 6XSW chain J against the predicted model Q9UM47: TM-score 0.96, RMSD 1.14 Å
- 6XSW chain J against the predicted model Q9UM47: TM-score 0.96, RMSD 1.14 Å
- 5CZX chain A against the predicted model Q9UM47: TM-score 0.96, RMSD 1.28 Å
- 5CZX chain A against the predicted model Q9UM47: TM-score 0.96, RMSD 1.28 Å
Elsewhere
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