UniProt Q9UK80
Ubiquitin carboxyl-terminal hydrolase 21 (Q9UK80)
Ubiquitin carboxyl-terminal hydrolase 21 (UniProt Q9UK80), EC 3.1.2.15, 3.4.19.12: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 61 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9UK80
- Protein
- Ubiquitin carboxyl-terminal hydrolase 21
- EC
- 3.1.2.15, 3.4.19.12
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 61 · 7 records with a druggable one
Structures
7 records of Q9UK80 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Y5B | Structure of USP21 in complex with linear diubiquitin-aldehyde | x-ray diffraction | A, E | ZN, SO4 | 7 (best 0.80) |
| 2Y5B | Structure of USP21 in complex with linear diubiquitin-aldehyde | x-ray diffraction | A, E | ZN, SO4 | 7 (best 0.80) |
| 3I3T | Crystal structure of covalent ubiquitin-USP21 complex | x-ray diffraction | A, C, E, G | ZN, NEH | 18 (best 0.77) |
| 3I3T | Crystal structure of covalent ubiquitin-USP21 complex | x-ray diffraction | A, C, E, G | ZN, NEH | 18 (best 0.77) |
| 3MTN | Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor | x-ray diffraction | A, C | ZN, CL | 4 (best 0.78) |
| 3MTN | USP21 in complex with a ubiquitin-based, USP21-specific inhibitor | x-ray diffraction | A, C | ZN, CL | 4 (best 0.78) |
| Q9UK80 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 21 (Q9UK80) | predicted | A | — | 3 (best 0.74) |
Ligands
Experiment against prediction
- 3I3T chain A against the predicted model Q9UK80: TM-score 0.99, RMSD 0.69 Å
- 3I3T chain A against the predicted model Q9UK80: TM-score 0.99, RMSD 0.69 Å
- 3I3T chain G against the predicted model Q9UK80: TM-score 0.99, RMSD 0.69 Å
- 3I3T chain G against the predicted model Q9UK80: TM-score 0.99, RMSD 0.69 Å
- 3I3T chain C against the predicted model Q9UK80: TM-score 0.99, RMSD 0.72 Å
- 3I3T chain C against the predicted model Q9UK80: TM-score 0.99, RMSD 0.72 Å
- 2Y5B chain A against the predicted model Q9UK80: TM-score 0.99, RMSD 0.79 Å
- 2Y5B chain A against the predicted model Q9UK80: TM-score 0.99, RMSD 0.79 Å
- 3MTN chain C against the predicted model Q9UK80: TM-score 0.99, RMSD 0.81 Å
- 3MTN chain C against the predicted model Q9UK80: TM-score 0.99, RMSD 0.81 Å
Elsewhere
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