UniProt Q9UHC9
Isoform 2 of NPC1-like intracellular cholesterol transporter 1 (Q9UHC9)
Isoform 2 of NPC1-like intracellular cholesterol transporter 1 (UniProt Q9UHC9): 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 57 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9UHC9
- Protein
- Isoform 2 of NPC1-like intracellular cholesterol transporter 1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 57 · 4 records with a druggable one
Structures
9 records of Q9UHC9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QNT | NPC1L1 (NTD) Structure | x-ray diffraction | A | — | — |
| 3QNT | NPC1L1 (ntd) structure | x-ray diffraction | A | — | — |
| 7N4U | Structure of human NPC1L1 | electron microscopy | A, B | NAG, CLR, VIV, POV | 16 (best 0.88) |
| 7N4U | Structure of human NPC1L1 | electron microscopy | A, B | NAG, CLR, VIV, POV | — |
| 7N4V | Structure of cholesterol-bound human NPC1L1 | electron microscopy | A, B | NAG, CLR, POV | 19 (best 0.89) |
| 7N4V | Structure of cholesterol-bound human NPC1L1 | electron microscopy | A, B | NAG, CLR, POV | — |
| 7N4X | Structure of human NPC1L1 mutant-W347R | electron microscopy | A | NAG, CLR | 9 (best 0.89) |
| 7N4X | Structure of human NPC1L1 mutant-W347R | electron microscopy | A | NAG, CLR | — |
| Q9UHC9 | AlphaFold monomer V2.0 prediction for NPC1-like intracellular cholesterol transporter 1 (Q9UHC9) | predicted | A | — | 13 (best 0.91) |
Ligands
- CLR · Cholesterol · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- VIV · (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol · in 2 records
Experiment against prediction
- 7N4X chain A against the predicted model Q9UHC9: TM-score 0.98, RMSD 1.56 Å
- 7N4X chain A against the predicted model Q9UHC9: TM-score 0.98, RMSD 1.56 Å
- 7N4V chain A against the predicted model Q9UHC9: TM-score 0.98, RMSD 1.62 Å
- 7N4V chain A against the predicted model Q9UHC9: TM-score 0.98, RMSD 1.62 Å
- 7N4U chain A against the predicted model Q9UHC9: TM-score 0.98, RMSD 1.66 Å
- 7N4U chain A against the predicted model Q9UHC9: TM-score 0.98, RMSD 1.66 Å
- 3QNT chain A against the predicted model Q9UHC9: TM-score 0.96, RMSD 1.33 Å
- 3QNT chain A against the predicted model Q9UHC9: TM-score 0.96, RMSD 1.33 Å
Elsewhere
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