UniProt Q9UEW8
STE20/SPS1-related proline-alanine-rich protein kinase (Q9UEW8)
STE20/SPS1-related proline-alanine-rich protein kinase (UniProt Q9UEW8), EC 2.7.11.1: 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9UEW8
- Protein
- STE20/SPS1-related proline-alanine-rich protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 1 record with a druggable one
Structures
3 records of Q9UEW8 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7O86 | 1.73A X-ray crystal structure of the conserved C-terminal (CCT) of human SPAK | x-ray diffraction | A, B | NA, CA, MG | 3 (best 0.47) |
| 7O86 | 1.73A X-ray crystal structure of the conserved C-terminal (cct) of human spak | x-ray diffraction | A, B | NA, CA | — |
| Q9UEW8 | AlphaFold monomer V2.0 prediction for STE20/SPS1-related proline- alanine-rich protein kinase… | predicted | A | — | 7 (best 0.74) |
Ligands
Experiment against prediction
- 7O86 chain A against the predicted model Q9UEW8: TM-score 0.96, RMSD 0.78 Å
- 7O86 chain A against the predicted model Q9UEW8: TM-score 0.96, RMSD 0.78 Å
- 7O86 chain B against the predicted model Q9UEW8: TM-score 0.92, RMSD 1.22 Å
- 7O86 chain B against the predicted model Q9UEW8: TM-score 0.92, RMSD 1.22 Å
Elsewhere
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