UniProt Q9UEF7
Klotho (Q9UEF7)
Klotho (UniProt Q9UEF7), EC 3.2.1.31: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UEF7
- Protein
- Klotho
- EC
- 3.2.1.31
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 29 · 3 records with a druggable one
Structures
6 records of Q9UEF7 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5W21 | Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex | x-ray diffraction | A | NAG, ZN | — |
| 5W21 | Crystal structure of a 1:1:1 FGF23-FGFR1C-aklotho ternary complex | x-ray diffraction | A | NAG, ZN | — |
| 7YSH | Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | electron microscopy | A | ZN | 7 (best 0.81) |
| 7YSU | Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | electron microscopy | A | ZN | 12 (best 0.74) |
| 7YSW | Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex | electron microscopy | A | ZN | 10 (best 0.73) |
| Q9UEF7 | AlphaFold monomer V2.0 prediction for klotho (Q9UEF7) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5W21 chain A against the predicted model Q9UEF7: TM-score 0.97, RMSD 1.82 Å
- 5W21 chain A against the predicted model Q9UEF7: TM-score 0.97, RMSD 1.82 Å
- 7YSU chain A against the predicted model Q9UEF7: TM-score 0.96, RMSD 1.98 Å
- 7YSH chain A against the predicted model Q9UEF7: TM-score 0.96, RMSD 2.04 Å
- 7YSW chain A against the predicted model Q9UEF7: TM-score 0.96, RMSD 2.14 Å
Elsewhere
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