UniProt Q9S5X0
K(+)-stimulated pyrophosphate-energized sodium pump (Q9S5X0)
K(+)-stimulated pyrophosphate-energized sodium pump (UniProt Q9S5X0), EC 3.6.1.1, 7.2.3.-: 14 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 126 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9S5X0
- Protein
- K(+)-stimulated pyrophosphate-energized sodium pump
- EC
- 3.6.1.1, 7.2.3.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 126 · 7 records with a druggable one
Structures
15 records of Q9S5X0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4AV3 | Crystal structure of Thermotoga Maritima sodium pumping membrane integral pyrophosphatase with… | x-ray diffraction | A, B | — | — |
| 4AV3 | Crystal structure of thermotoga maritima sodium pumping membrane integral pyrophosphatase with… | x-ray diffraction | A, B | — | — |
| 4AV6 | Crystal structure of Thermotoga maritima sodium pumping membrane integral pyrophosphatase at 4 A in… | x-ray diffraction | A, B | — | — |
| 4AV6 | Crystal structure of thermotoga maritima sodium pumping membrane integral pyrophosphatase at 4 a in… | x-ray diffraction | A, B | — | — |
| 5LZQ | Crystal structure of Thermotoga maritima sodium pumping membrane integral pyrophosphatase in… | x-ray diffraction | A, B | MG, 2PN, NA | 18 (best 0.78) |
| 5LZQ | Crystal structure of thermotoga maritima sodium pumping membrane integral pyrophosphatase in… | x-ray diffraction | A, B | MG, 2PN, NA | — |
| 5LZR | Crystal structure of Thermotoga maritima sodium pumping membrane integral pyrophosphatase in… | x-ray diffraction | A, B | WO4, MG | 20 (best 0.75) |
| 5LZR | Crystal structure of thermotoga maritima sodium pumping membrane integral pyrophosphatase in… | x-ray diffraction | A, B | WO4, MG | — |
| 6QXA | Structure of membrane bound pyrophosphatase from Thermotoga maritima in complex with… | x-ray diffraction | A, B, C, D | MG, 2PN, NA, K, GQB, D1D | 20 (best 0.82) |
| 6QXA | Structure of membrane bound pyrophosphatase from thermotoga maritima in complex with… | x-ray diffraction | A, B, C, D | MG, 2PN, NA, K, GQB, D1D | — |
| 8B21 | Time-resolved structure of K+-dependent Na+-PPase from Thermotoga maritima 0-60-seconds post… | x-ray diffraction | A, B | — | 15 (best 0.79) |
| 8B22 | Time-resolved structure of K+-dependent Na+-PPase from Thermotoga maritima 300-seconds post… | x-ray diffraction | A, B | DPO, MG | 17 (best 0.78) |
| 8B23 | Time-resolved structure of K+-dependent Na+-PPase from Thermotoga maritima 600-seconds post… | x-ray diffraction | A, B | DPO, MG | 20 (best 0.81) |
| 8B24 | Time-resolved structure of K+-dependent Na+-PPase from Thermotoga maritima 3600-seconds post… | x-ray diffraction | A, B | DPO, MG, K, PO4 | 16 (best 0.78) |
| Q9S5X0 | AlphaFold monomer V2.0 prediction for K(+)-stimulated pyrophosphate- energized sodium pump (Q9S5X0) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 9 records
- 2PN · Imidodiphosphoric acid · in 4 records
- NA · Sodium ion · in 4 records
- DPO · Diphosphate · in 3 records
- K · Potassium ion · in 3 records
- D1D · (4S,5S)-1,2-dithiane-4,5-diol · in 2 records
- GQB · ~{N}-[(2-azanyl-3~{H}-1,3-benzothiazol-6-yl)methyl]-1~{H}-indole-2-carboxamide · in 2 records
- WO4 · Tungstate(vi)ion · in 2 records
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 5LZQ chain A against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.42 Å
- 5LZQ chain A against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.42 Å
- 5LZQ chain B against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.46 Å
- 6QXA chain C against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.50 Å
- 6QXA chain A against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.50 Å
- 6QXA chain A against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.50 Å
- 6QXA chain D against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.52 Å
- 6QXA chain D against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.52 Å
- 6QXA chain B against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.56 Å
- 6QXA chain B against the predicted model Q9S5X0: TM-score 1.00, RMSD 0.56 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.