UniProt Q9PPB4
4-hydroxy-tetrahydrodipicolinate synthase (Q9PPB4)
4-hydroxy-tetrahydrodipicolinate synthase (UniProt Q9PPB4), EC 4.3.3.7: 86 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 388 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9PPB4
- Protein
- 4-hydroxy-tetrahydrodipicolinate synthase
- EC
- 4.3.3.7
- Experimental structures
- 86
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 388 · 30 records with a druggable one
Structures
87 records of Q9PPB4 in the MolNFT archive: 86 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LER | Crystal Structure of Dihydrodipicolinate Synthase from Campylobacter jejuni subsp. jejuni NCTC 11168 | x-ray diffraction | A, B, C, D | — | — |
| 3LER | Crystal structure of dihydrodipicolinate synthase from campylobacter jejuni subsp. jejuni nctc 11168 | x-ray diffraction | A, B, C, D | — | — |
| 3M5V | Crystal Structure of Dihydrodipicolinate Synthase from Campylobacter jejuni | x-ray diffraction | A, B, C, D | — | — |
| 3M5V | Crystal structure of dihydrodipicolinate synthase from campylobacter jejuni | x-ray diffraction | A, B, C, D | — | — |
| 4LY8 | dihydrodipicolinate synthase from C. jejuni with pyruvate bound to the active site | x-ray diffraction | A, B, C, D | — | — |
| 4LY8 | Dihydrodipicolinate synthase from C. jejuni with pyruvate bound to the active site | x-ray diffraction | A, B, C, D | — | — |
| 4M19 | dihydrodipicolinate synthase from C. jejuni with pyruvate bound to the active site and Lysine bound… | x-ray diffraction | A, B, C, D | — | — |
| 4M19 | Dihydrodipicolinate synthase from C. jejuni with pyruvate bound to the active site and lysine bound… | x-ray diffraction | A, B, C, D | — | — |
| 4MLJ | dihydrodipicolinate synthase from C. jejuni, Y110F mutation with pyruvate bound to the active site | x-ray diffraction | A, B, C, D | — | — |
| 4MLJ | Dihydrodipicolinate synthase from C. jejuni, Y110F mutation with pyruvate bound to the active site | x-ray diffraction | A, B, C, D | — | — |
| 4MLR | dihydrodipicolinate synthase from C. jejuni, Y110F mutation with pyruvate and Lysine | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4MLR | Dihydrodipicolinate synthase from C. jejuni, Y110F mutation with pyruvate and lysine | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4R53 | dihydrodipicolinate synthase from C. jejuni with vacant active site and vacant allosteric site | x-ray diffraction | A, B, C, D | — | — |
| 4R53 | Dihydrodipicolinate synthase from C. jejuni with vacant active site and vacant allosteric site | x-ray diffraction | A, B, C, D | — | — |
| 5F1U | biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from… | x-ray diffraction | A, B, C, D | 3VN, CL | — |
| 5F1U | Biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from… | x-ray diffraction | A, B, C, D | — | — |
| 5F1V | biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from… | x-ray diffraction | A, B, C, D | 3VN | 9 (best 0.73) |
| 5F1V | Biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from… | x-ray diffraction | A, B, C, D | — | — |
| 6TZU | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, N84A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KG5 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56W mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | 15 (best 0.78) |
| 7KG5 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H56W mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KG9 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56W mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | LYS, MG | 14 (best 0.77) |
| 7KG9 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H56W mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KH4 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H56W mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | — |
| 7KK1 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | LYS, MG | 13 (best 0.75) |
| 7KK1 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, N84A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KKD | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | 15 (best 0.75) |
| 7KKD | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, N84A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | — |
| 7KKG | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, N84D mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, NA | — |
| 7KKT | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84D mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | 14 (best 0.74) |
| 7KKT | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, N84D mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | — |
| 7KLQ | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | 12 (best 0.79) |
| 7KLQ | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H59A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KLS | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H59A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KLT | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H59N mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KLY | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59N mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | LYS, MG | 14 (best 0.75) |
| 7KLY | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H59N mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KM0 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, 3VN | 12 (best 0.80) |
| 7KM0 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H59A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, 3VN | — |
| 7KM1 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59N mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | 13 (best 0.76) |
| 7KM1 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H59N mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | 3VN, MG | — |
| 7KN2 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | 13 (best 0.75) |
| 7KN2 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KN9 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, LYS | 13 (best 0.69) |
| 7KN9 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KNZ | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, 3VN | 12 (best 0.74) |
| 7KNZ | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, 3VN | — |
| 7KO1 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88D mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | 13 (best 0.74) |
| 7KO1 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88D mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KO3 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88D mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KOC | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88Q mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | 12 (best 0.75) |
| 7KOC | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88Q mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KPC | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88Q mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | LYS, MG | 12 (best 0.78) |
| 7KPC | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88Q mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KPE | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88Q mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, 3VN | — |
| 7KPE | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, E88Q mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG, 3VN | — |
| 7KR7 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | LYS, MG | 11 (best 0.70) |
| 7KR7 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H56A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
| 7KR8 | Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | 11 (best 0.72) |
| 7KR8 | Dihydrodipicolinate synthase (dhdps) from C.JEJUNI, H56A mutant with pyruvate bound in the active… | x-ray diffraction | A, B, C, D, E, F | MG | — |
27 records more on the page itself.
Ligands
Experiment against prediction
- 7KH4 chain C against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.20 Å
- 7KH4 chain A against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KTO chain A against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KTO chain A against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KH4 chain F against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KH4 chain B against the predicted model Q9PPB4: TM-score 0.98, RMSD 0.21 Å
- 7KKD chain A against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KKD chain A against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KPE chain D against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
- 7KPE chain D against the predicted model Q9PPB4: TM-score 1.00, RMSD 0.21 Å
Elsewhere
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