UniProt Q9NZ45
CDGSH iron-sulfur domain-containing protein 1 (Q9NZ45)
CDGSH iron-sulfur domain-containing protein 1 (UniProt Q9NZ45): 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9NZ45
- Protein
- CDGSH iron-sulfur domain-containing protein 1
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 1 · 0 records with a druggable one
Structures
23 records of Q9NZ45 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QD0 | Crystal structure of mitoNEET | x-ray diffraction | A, B | — | — |
| 2QD0 | Crystal structure of mitoneet | x-ray diffraction | A, B | — | — |
| 2R13 | Crystal structure of human mitoNEET reveals a novel [2Fe-2S] cluster coordination | x-ray diffraction | A | — | — |
| 2R13 | Crystal structure of human mitoneet reveals a novel [2FE-2S] cluster coordination | x-ray diffraction | A | — | — |
| 3EW0 | The novel 2Fe-2S outer mitochondrial protein mitoNEET displays conformational flexibility in its… | x-ray diffraction | A, B | — | — |
| 3EW0 | The novel 2FE-2S outer mitochondrial protein mitoneet displays conformational flexibility in its… | x-ray diffraction | A, B | — | — |
| 3LPQ | Human MitoNEET with 2Fe-2S Coordinating Ligand His 87 Replaced With Cys | x-ray diffraction | A, B | — | — |
| 3LPQ | Human mitoneet with 2FE-2S coordinating ligand his 87 replaced with cys | x-ray diffraction | A, B | — | — |
| 3REE | Crystal structure of mitoNEET | x-ray diffraction | A | — | — |
| 3REE | Crystal structure of mitoneet | x-ray diffraction | A | — | — |
| 4EZF | The Crystal Structure of a Human MitoNEET mutant with an Ala inserted between Asp 67 and Lys 68 | x-ray diffraction | A, B | — | — |
| 4EZF | The crystal structure of a human mitoneet mutant with an ala inserted between asp 67 and lys 68 | x-ray diffraction | A, B | — | — |
| 4F1E | The Crystal Structure of a Human MitoNEET mutant with Asp 67 replaced by a Gly | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | — |
| 4F1E | The crystal structure of a human mitoneet mutant with asp 67 replaced by a gly | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | — |
| 4F28 | The Crystal Structure of a Human MitoNEET mutant with Met 62 Replaced by a Gly | x-ray diffraction | A, B | — | — |
| 4F28 | The crystal structure of a human mitoneet mutant with met 62 replaced by a gly | x-ray diffraction | A, B | — | — |
| 4F2C | The Crystal Structure of a Human MitoNEET double mutant in which Gly 66 are Asp 67 are both… | x-ray diffraction | A, B | — | — |
| 4F2C | The crystal structure of a human mitoneet double mutant in which gly 66 are asp 67 are both… | x-ray diffraction | A, B | — | — |
| 6DE9 | mitoNEET bound to furosemide | x-ray diffraction | A | FES, FUN | 1 (best 0.28) |
| 6DE9 | Mitoneet bound to furosemide | x-ray diffraction | A | FES, FUN | — |
| 7P0O | mitoNEET bound to M1 molecule | x-ray diffraction | A, B | FES, 49I, 4OY | — |
| 7P0O | Mitoneet bound to M1 molecule | x-ray diffraction | A, B | FES, 49I, 4OY | — |
| Q9NZ45 | AlphaFold monomer V2.0 prediction for cdgsh iron-sulfur domain- containing protein 1 (Q9NZ45) | predicted | A | — | — |
Ligands
- FES · Fe2/s2 (inorganic) cluster · in 4 records
- 49I · 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid · in 2 records
- 4OY · 2-benzamido-4-[(2~{S})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid · in 2 records
- FUN · 5-(aminosulfonyl)-4-chloro-2-[(2-furylmethyl) amino]benzoic acid · in 2 records
Experiment against prediction
- 2QD0 chain A against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.49 Å
- 2QD0 chain A against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.49 Å
- 4F28 chain B against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.51 Å
- 4F28 chain B against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.51 Å
- 4F2C chain B against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.50 Å
- 4F2C chain B against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.50 Å
- 4F28 chain A against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.53 Å
- 4F28 chain A against the predicted model Q9NZ45: TM-score 0.97, RMSD 0.53 Å
- 7P0O chain B against the predicted model Q9NZ45: TM-score 0.96, RMSD 0.85 Å
- 7P0O chain B against the predicted model Q9NZ45: TM-score 0.96, RMSD 0.85 Å
Elsewhere
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