UniProt Q9NWT8
Aurora kinase A-interacting protein (Q9NWT8)
Aurora kinase A-interacting protein (UniProt Q9NWT8): 48 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 120 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NWT8
- Protein
- Aurora kinase A-interacting protein
- Experimental structures
- 48
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 120 · 42 records with a druggable one
Structures
49 records of Q9NWT8 in the MolNFT archive: 48 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J9M | Structure of the human mitochondrial ribosome (class 1) | electron microscopy | A3 | — | — |
| 6NU2 | Structural insights into unique features of the human mitochondrial ribosome recycling | electron microscopy | A3 | — | — |
| 6NU3 | Structural insights into unique features of the human mitochondrial ribosome recycling | electron microscopy | A3 | MG | 2 (best 0.88) |
| 6RW4 | Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF3 | electron microscopy | 3 | MG | 4 (best 0.87) |
| 6RW5 | Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF2 and IF3 | electron microscopy | 3 | MG | 4 (best 0.87) |
| 6VLZ | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassI) | electron microscopy | A3 | — | 2 (best 0.88) |
| 6VMI | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII) | electron microscopy | A3 | — | 4 (best 0.87) |
| 6ZM5 | Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide | electron microscopy | A3 | MG | 3 (best 0.88) |
| 6ZM6 | Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA | electron microscopy | A3 | MG | 3 (best 0.88) |
| 6ZS9 | Human mitochondrial ribosome in complex with ribosome recycling factor | electron microscopy | A3 | MG | — |
| 6ZSA | Human mitochondrial ribosome bound to mRNA, A-site tRNA and P-site tRNA | electron microscopy | A3 | — | 3 (best 0.88) |
| 6ZSB | Human mitochondrial ribosome in complex with mRNA and P-site tRNA | electron microscopy | A3 | — | — |
| 6ZSC | Human mitochondrial ribosome in complex with E-site tRNA | electron microscopy | A3 | — | 3 (best 0.87) |
| 6ZSD | Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA | electron microscopy | A3 | — | 3 (best 0.87) |
| 6ZSE | Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA | electron microscopy | A3 | MG | — |
| 6ZSG | Human mitochondrial ribosome in complex with mRNA, A-site tRNA, P-site tRNA and E-site tRNA | electron microscopy | A3 | — | 3 (best 0.88) |
| 7A5F | Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs | electron microscopy | d6 | — | 3 (best 0.88) |
| 7A5G | Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA | electron microscopy | d6 | — | 4 (best 0.87) |
| 7A5I | Structure of the human mitoribosome with A- P-and E-site mt-tRNAs | electron microscopy | d6 | — | 3 (best 0.87) |
| 7A5K | Structure of the human mitoribosome in the post translocation state bound to mtEF-G1 | electron microscopy | d6 | — | 4 (best 0.88) |
| 7L08 | Cryo-EM structure of the human 55S mitoribosome-RRFmt complex. | electron microscopy | A3 | — | 1 (best 0.85) |
| 7OG4 | Human mitochondrial ribosome in complex with P/E-tRNA | electron microscopy | A3 | — | 2 (best 0.87) |
| 7P2E | Human mitochondrial ribosome small subunit in complex with IF3, GMPPMP and streptomycin | electron microscopy | 3 | MG | 5 (best 0.87) |
| 7PNX | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | 3 | MG | 2 (best 0.85) |
| 7PNY | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | 3 | MG | 2 (best 0.86) |
| 7PNZ | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | 3 | MG | 2 (best 0.85) |
| 7PO0 | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | 3 | MG | 2 (best 0.87) |
| 7PO1 | Initiation complex of human mitochondrial ribosome small subunit with IF3 | electron microscopy | 3 | MG | 3 (best 0.87) |
| 7PO2 | Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet and mRNA | electron microscopy | 3 | MG | 3 (best 0.87) |
| 7PO3 | Human mitochondrial ribosome small subunit | electron microscopy | 3 | MG | 3 (best 0.87) |
| 7QI4 | Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA) | electron microscopy | A3 | MG | 3 (best 0.87) |
| 7QI5 | Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution | electron microscopy | A3 | MG | 3 (best 0.88) |
| 7QI6 | Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution | electron microscopy | A3 | MG | 3 (best 0.86) |
| 8ANY | Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA | electron microscopy | A3 | MG, K | 3 (best 0.87) |
| 8CSQ | Human mitochondrial small subunit assembly intermediate (State B) | electron microscopy | 3 | — | 1 (best 0.80) |
| 8CSR | Human mitochondrial small subunit assembly intermediate (State C) | electron microscopy | 3 | — | 1 (best 0.78) |
| 8CSS | Human mitochondrial small subunit assembly intermediate (State D) | electron microscopy | 3 | — | 2 (best 0.86) |
| 8CST | Human mitochondrial small subunit assembly intermediate (State E) | electron microscopy | 3 | — | — |
| 8CSU | Human mitochondrial small subunit assembly intermediate (State C*) | electron microscopy | 3 | — | 1 (best 0.77) |
| 8K2A | Cryo-EM structure of the human 55S mitoribosome with Tigecycline | electron microscopy | Sn | — | 3 (best 0.86) |
| 8OIR | 55S human mitochondrial ribosome with mtRF1 and P-site tRNA | electron microscopy | AD | K, MG | 3 (best 0.88) |
| 8OIS | 28S human mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA | electron microscopy | AD | MG | 4 (best 0.86) |
| 8QRK | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 1 | electron microscopy | 3 | MG | 4 (best 0.85) |
| 8QRL | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 2 | electron microscopy | 3 | MG | 2 (best 0.85) |
| 8QRM | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 3 | electron microscopy | 3 | MG | 4 (best 0.86) |
| 8QRN | mt-SSU in GTPBP8 knock-out cells, state 4 | electron microscopy | 3 | MG | 4 (best 0.86) |
| 8XT0 | Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline | electron microscopy | Sn | — | 3 (best 0.86) |
| 8XT2 | Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline | electron microscopy | Sn | — | 3 (best 0.88) |
| Q9NWT8 | AlphaFold monomer V2.0 prediction for aurora kinase a-interacting protein (Q9NWT8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8CSS chain 3 against the predicted model Q9NWT8: TM-score 0.97, RMSD 0.58 Å
- 8CST chain 3 against the predicted model Q9NWT8: TM-score 0.96, RMSD 0.61 Å
- 7QI4 chain A3 against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.65 Å
- 8ANY chain A3 against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.67 Å
- 8OIS chain AD against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.67 Å
- 7QI5 chain A3 against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.67 Å
- 8OIR chain AD against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.67 Å
- 8XT0 chain Sn against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.70 Å
- 7QI6 chain A3 against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.71 Å
- 8K2A chain Sn against the predicted model Q9NWT8: TM-score 0.95, RMSD 0.71 Å
Elsewhere
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