UniProt Q9NW38
E3 ubiquitin-protein ligase FANCL (Q9NW38)
E3 ubiquitin-protein ligase FANCL (UniProt Q9NW38), EC 2.3.2.27: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9NW38
- Protein
- E3 ubiquitin-protein ligase FANCL
- EC
- 2.3.2.27
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 22 · 5 records with a druggable one
Structures
11 records of Q9NW38 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ZQS | Human FANCL central domain | x-ray diffraction | A, B | — | — |
| 3ZQS | Human fancl central domain | x-ray diffraction | A, B | — | — |
| 4CCG | Structure of an E2-E3 complex | x-ray diffraction | X, Y | — | — |
| 4CCG | Structure of an E2-E3 complex | x-ray diffraction | X, Y | — | — |
| 7KZP | Structure of the human Fanconi anaemia Core complex | electron microscopy | L, M | ZN | 3 (best 0.88) |
| 7KZQ | Structure of the human Fanconi anaemia Core-ID complex | electron microscopy | L, M | ZN | 4 (best 0.87) |
| 7KZR | Structure of the human Fanconi Anaemia Core-UBE2T-ID complex | electron microscopy | L, M | ZN | 5 (best 0.86) |
| 7KZS | Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in open state | electron microscopy | L, M | ZN | 6 (best 0.82) |
| 7KZT | Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in intermediate state | electron microscopy | L, M | ZN | — |
| 7KZV | Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in closed state | electron microscopy | L, M | ZN | 4 (best 0.86) |
| Q9NW38 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase fancl (Q9NW38) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
Experiment against prediction
- 3ZQS chain A against the predicted model Q9NW38: TM-score 0.96, RMSD 1.05 Å
- 3ZQS chain A against the predicted model Q9NW38: TM-score 0.96, RMSD 1.05 Å
- 3ZQS chain B against the predicted model Q9NW38: TM-score 0.96, RMSD 1.27 Å
- 3ZQS chain B against the predicted model Q9NW38: TM-score 0.96, RMSD 1.27 Å
- 4CCG chain Y against the predicted model Q9NW38: TM-score 0.95, RMSD 0.65 Å
- 4CCG chain Y against the predicted model Q9NW38: TM-score 0.95, RMSD 0.65 Å
- 4CCG chain X against the predicted model Q9NW38: TM-score 0.88, RMSD 1.53 Å
- 4CCG chain X against the predicted model Q9NW38: TM-score 0.88, RMSD 1.53 Å
- 7KZV chain M against the predicted model Q9NW38: TM-score 0.72, RMSD 3.64 Å
- 7KZS chain M against the predicted model Q9NW38: TM-score 0.71, RMSD 2.51 Å
Elsewhere
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