UniProt Q9NVW2
E3 ubiquitin-protein ligase RLIM (Q9NVW2)
E3 ubiquitin-protein ligase RLIM (UniProt Q9NVW2), EC 2.3.2.27: 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9NVW2
- Protein
- E3 ubiquitin-protein ligase RLIM
- EC
- 2.3.2.27
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 2 records with a druggable one
Structures
7 records of Q9NVW2 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6W7Z | RNF12 RING domain in complex with Ube2d2 | x-ray diffraction | B | ZN | 1 (best 0.41) |
| 6W7Z | RNF12 ring domain in complex with UBE2D2 | x-ray diffraction | B | ZN | — |
| 6W9A | RNF12 RING domain in complex with Ube2e2 | x-ray diffraction | B, D | ZN | 3 (best 0.35) |
| 6W9A | RNF12 ring domain in complex with UBE2E2 | x-ray diffraction | B, D | ZN | — |
| 6W9D | RNF12 RING domain in complex with a Ube2d2~Ub conjugate | x-ray diffraction | B, E, H | ZN, IOD | 8 (best 0.67) |
| 6W9D | RNF12 ring domain in complex with a UBE2D2~UB conjugate | x-ray diffraction | B, E, H | ZN, IOD | — |
| Q9NVW2 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase rlim (Q9NVW2) | predicted | A | — | 5 (best 0.65) |
Ligands
Experiment against prediction
- 6W7Z chain B against the predicted model Q9NVW2: TM-score 0.98, RMSD 0.43 Å
- 6W7Z chain B against the predicted model Q9NVW2: TM-score 0.98, RMSD 0.43 Å
- 6W9A chain B against the predicted model Q9NVW2: TM-score 0.94, RMSD 1.05 Å
- 6W9A chain B against the predicted model Q9NVW2: TM-score 0.94, RMSD 1.05 Å
- 6W9A chain D against the predicted model Q9NVW2: TM-score 0.94, RMSD 0.82 Å
- 6W9D chain B against the predicted model Q9NVW2: TM-score 0.92, RMSD 0.84 Å
- 6W9D chain B against the predicted model Q9NVW2: TM-score 0.92, RMSD 0.84 Å
- 6W9D chain H against the predicted model Q9NVW2: TM-score 0.92, RMSD 1.07 Å
- 6W9D chain E against the predicted model Q9NVW2: TM-score 0.92, RMSD 1.10 Å
- 6W9D chain E against the predicted model Q9NVW2: TM-score 0.92, RMSD 1.10 Å
Elsewhere
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