UniProt Q9NSY1
BMP-2-inducible protein kinase (Q9NSY1)
BMP-2-inducible protein kinase (UniProt Q9NSY1), EC 2.7.11.1: 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9NSY1
- Protein
- BMP-2-inducible protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 5 · 1 record with a druggable one
Structures
11 records of Q9NSY1 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4W9W | Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762 | x-ray diffraction | A | — | — |
| 4W9W | Crystal structure of bmp-2-inducible kinase in complex with small molecule azd-7762 | x-ray diffraction | A | — | — |
| 4W9X | Crystal Structure of BMP-2-inducible kinase in complex with baricitinib | x-ray diffraction | A | — | — |
| 4W9X | Crystal structure of bmp-2-inducible kinase in complex with baricitinib | x-ray diffraction | A | — | — |
| 5I3O | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor | x-ray diffraction | A, B | IDV, SO4 | — |
| 5I3O | Crystal structure of bmp-2-inducible kinase in complex with an indazole inhibitor | x-ray diffraction | A, B | — | — |
| 5I3R | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor | x-ray diffraction | A, B | IDK, PO4 | 5 (best 0.77) |
| 5I3R | Crystal structure of bmp-2-inducible kinase in complex with an indazole inhibitor | x-ray diffraction | A, B | — | — |
| 5IKW | Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor | x-ray diffraction | A | 6BU | — |
| 5IKW | Crystal structure of bmp-2-inducible kinase in complex with an indazole inhibitor | x-ray diffraction | A | — | — |
| Q9NSY1 | AlphaFold monomer V2.0 prediction for bmp-2-inducible protein kinase (Q9NSY1) | predicted | A | — | — |
Ligands
- 6BU · N-(6-{3-[(cyclopropylsulfonyl)amino]phenyl}-1H-indazol-3-yl)cyclopropanecarboxamide · in 1 record
- IDK · N-[6-(3-{[(cyclopropylmethyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]cyclopropanecarboxamide · in 1 record
- IDV · N-(6-{3-[(dimethylsulfamoyl)amino]phenyl}-1H-indazol-3-yl)cyclopropanecarboxamide · in 1 record
- PO4 · Phosphate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5IKW chain A against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.98 Å
- 5IKW chain A against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.98 Å
- 5I3O chain B against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.96 Å
- 5I3O chain B against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.96 Å
- 5I3R chain B against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.96 Å
- 5I3R chain B against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.96 Å
- 5I3R chain A against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.97 Å
- 5I3R chain A against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.97 Å
- 5I3O chain A against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.98 Å
- 5I3O chain A against the predicted model Q9NSY1: TM-score 0.98, RMSD 0.98 Å
Elsewhere
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