UniProt Q9K5E4
S-adenosylmethionine synthase (Q9K5E4)
S-adenosylmethionine synthase (UniProt Q9K5E4), EC 2.5.1.6: 3 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 51 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9K5E4
- Protein
- S-adenosylmethionine synthase
- EC
- 2.5.1.6
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 51 · 3 records with a druggable one
Structures
4 records of Q9K5E4 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JZG | C. glutamicum S-adenosylmethionine synthase co-crystallized with Adenosine, triphosphate, and SAM | x-ray diffraction | A, B, C, D | ADN, 3PO, SAM, POP, MG, K | 20 (best 0.83) |
| 8JZH | C. glutamicum S-adenosylmethionine synthase | x-ray diffraction | A, B, C | NA | 12 (best 0.75) |
| 8JZI | Mutant S-adenosylmethionine synthase from C. glutamicum | x-ray diffraction | A, B, C, D | NA | 19 (best 0.81) |
| Q9K5E4 | AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase (Q9K5E4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8JZI chain C against the predicted model Q9K5E4: TM-score 0.99, RMSD 1.00 Å
- 8JZI chain D against the predicted model Q9K5E4: TM-score 0.99, RMSD 1.04 Å
- 8JZG chain D against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.14 Å
- 8JZG chain C against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.18 Å
- 8JZI chain A against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.11 Å
- 8JZG chain A against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.02 Å
- 8JZH chain C against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.14 Å
- 8JZI chain B against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.31 Å
- 8JZG chain B against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.45 Å
- 8JZH chain A against the predicted model Q9K5E4: TM-score 0.98, RMSD 1.40 Å
Elsewhere
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