UniProt Q9HD23
Magnesium transporter MRS2 homolog, mitochondrial (Q9HD23)
Magnesium transporter MRS2 homolog, mitochondrial (UniProt Q9HD23): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 113 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9HD23
- Protein
- Magnesium transporter MRS2 homolog, mitochondrial
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 113 · 7 records with a druggable one
Structures
7 records of Q9HD23 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8IP4 | Cryo-EM structure of hMRS-highEDTA | electron microscopy | A, B, C, D, E | MG, CL | 15 (best 0.90) |
| 8IP5 | Cryo-EM structure of hMRS2-lowEDTA | electron microscopy | A, B, C, D, E | CL, MG | 17 (best 0.89) |
| 8IP6 | Cryo-EM structure of hMRS2-rest | electron microscopy | A, B, C, D, E | CL | 17 (best 0.88) |
| 8TS1 | Cryo-EM structure of human MRS2 with Mg2+ | electron microscopy | A, B, C, D, E | MG | 20 (best 0.89) |
| 8TS3 | Cryo-EM structure of human MRS2 with Ca2+ | electron microscopy | A, B, C, D, E | CA | 20 (best 0.88) |
| 8TUP | Cryo-EM structure of the human MRS2 magnesium channel under Mg2+-free condition | electron microscopy | A, B, C, D, E | MG | 20 (best 0.89) |
| Q9HD23 | AlphaFold monomer V2.0 prediction for magnesium transporter MRS2 homolog, mitochondrial (Q9HD23) | predicted | A | — | 4 (best 0.70) |
Ligands
Experiment against prediction
- 8IP4 chain A against the predicted model Q9HD23: TM-score 0.88, RMSD 2.60 Å
- 8IP5 chain A against the predicted model Q9HD23: TM-score 0.88, RMSD 2.61 Å
- 8TUP chain A against the predicted model Q9HD23: TM-score 0.87, RMSD 2.86 Å
- 8IP6 chain A against the predicted model Q9HD23: TM-score 0.86, RMSD 2.96 Å
- 8TS1 chain A against the predicted model Q9HD23: TM-score 0.86, RMSD 2.87 Å
- 8TS3 chain C against the predicted model Q9HD23: TM-score 0.85, RMSD 3.04 Å
- 8TS3 chain B against the predicted model Q9HD23: TM-score 0.85, RMSD 3.04 Å
- 8TS3 chain D against the predicted model Q9HD23: TM-score 0.85, RMSD 3.04 Å
- 8TS3 chain E against the predicted model Q9HD23: TM-score 0.85, RMSD 3.04 Å
- 8TS3 chain A against the predicted model Q9HD23: TM-score 0.85, RMSD 3.04 Å
Elsewhere
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