UniProt Q9HCL2
Glycerol-3-phosphate acyltransferase 1, mitochondrial (Q9HCL2)
Glycerol-3-phosphate acyltransferase 1, mitochondrial (UniProt Q9HCL2), EC 2.3.1.15: 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 32 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9HCL2
- Protein
- Glycerol-3-phosphate acyltransferase 1, mitochondrial
- EC
- 2.3.1.15
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 32 · 3 records with a druggable one
Structures
3 records of Q9HCL2 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8E4Y | Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with… | electron microscopy | A | UKL, NKO | 9 (best 0.74) |
| 8E50 | Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with CoA and… | electron microscopy | A | COA, NKO | 9 (best 0.73) |
| Q9HCL2 | AlphaFold monomer V2.0 prediction for glycerol-3-phosphate acyltransferase 1, mitochondrial (Q9HCL2) | predicted | A | — | 14 (best 0.76) |
Ligands
- NKO · (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate · in 2 records
- COA · Coenzyme A · in 1 record
- UKL · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2-oxohexadecyl)sulfanyl]ethyl}amino)propyl]amino}butyl dihydrogen diphosphate (non-preferred name) · in 1 record
Experiment against prediction
- 8E4Y chain A against the predicted model Q9HCL2: TM-score 0.98, RMSD 1.42 Å
- 8E50 chain A against the predicted model Q9HCL2: TM-score 0.98, RMSD 1.44 Å
Elsewhere
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