UniProt Q9HCC0
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Q9HCC0)
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (UniProt Q9HCC0), EC 6.4.1.4: 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 275 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9HCC0
- Protein
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- EC
- 6.4.1.4
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 275 · 14 records with a druggable one
Structures
15 records of Q9HCC0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8J4Z | Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate | electron microscopy | J, A, C, F, H, K | BTI, TW3 | 19 (best 0.82) |
| 8J73 | Methylcrotonoyl-CoA carboxylase core-Dimer | electron microscopy | G, H, I, J, K, L, M, N, O, P, Q, R | — | 20 (best 0.82) |
| 8J78 | Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state | electron microscopy | F, J, L, A, D, H | BTI | 20 (best 0.85) |
| 8J7D | Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state | electron microscopy | B, C, E, G, J, K | BTI | 20 (best 0.86) |
| 8J99 | Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state | electron microscopy | B, D, G, H, J, L | TW3 | 20 (best 0.81) |
| 8JAK | Human MCC in MCCU state | electron microscopy | E, B, D, H, J, L | — | 20 (best 0.82) |
| 8JAW | Human MCC in MCCD state | electron microscopy | B, D, G, I, J, L | BTI | 20 (best 0.86) |
| 8JXL | Human 3-methylcrotonyl-CoA carboxylase in MCCU state with MCoA | electron microscopy | B, A, D, G, I, K | TW3 | 18 (best 0.82) |
| 8JXM | Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state with MCoA | electron microscopy | K, A, C, H, E, J | TW3, BTI | 20 (best 0.82) |
| 8JXN | Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA | electron microscopy | D, G, I, B, K, A | BTI, TW3 | 18 (best 0.81) |
| 8K2V | 3-Methylcrotonyl-CoA Carboxylase in MCCD state with Acetyl CoA | electron microscopy | G, I, J, K, L, H | BTI, ACO | 20 (best 0.85) |
| 8XL6 | Structure of human 3-methylcrotonyl-CoA carboxylase at apo-state (MCC-Apo) | electron microscopy | B, D, F, H, J, L | BTN | 20 (best 0.82) |
| 8XL7 | Structure of human 3-methylcrotonyl-CoA carboxylase in complex with acetyl-CoA (MCC-ACO) | electron microscopy | B, D, F, H, J, L | BTN, ACO | 20 (best 0.81) |
| 8XL8 | Structure of human 3-methylcrotonyl-CoA carboxylase in complex with propionyl-CoA (MCC-PCO) | electron microscopy | B, D, F, H, J, L | BTN, 1VU | 20 (best 0.82) |
| Q9HCC0 | AlphaFold monomer V2.0 prediction for methylcrotonoyl-CoA carboxylase beta chain, mitochondrial… | predicted | A | — | — |
Ligands
- BTI · 5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl) pentanal · in 7 records
- TW3 · ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{S},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate · in 5 records
- BTN · Biotin · in 3 records
- ACO · Acetyl coenzyme *A · in 2 records
- 1VU · propionyl Coenzyme A · in 1 record
Experiment against prediction
- 8J73 chain G against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain M against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain L against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain R against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain H against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain N against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain K against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain Q against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain I against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
- 8J73 chain O against the predicted model Q9HCC0: TM-score 0.99, RMSD 0.64 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.