UniProt Q9HBH9
MAP kinase-interacting serine/threonine-protein kinase 2 (Q9HBH9)
MAP kinase-interacting serine/threonine-protein kinase 2 (UniProt Q9HBH9), EC 2.7.11.1: 26 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 22 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9HBH9
- Protein
- MAP kinase-interacting serine/threonine-protein kinase 2
- EC
- 2.7.11.1
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 22 · 10 records with a druggable one
Structures
27 records of Q9HBH9 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AC3 | Structure of human Mnk2 Kinase Domain | x-ray diffraction | A | — | — |
| 2AC3 | Structure of human MNK2 kinase domain | x-ray diffraction | A | — | — |
| 2AC5 | Structure of human Mnk2 Kinase Domain mutant D228G | x-ray diffraction | A | — | — |
| 2AC5 | Structure of human MNK2 kinase domain mutant D228G | x-ray diffraction | A | — | — |
| 2HW7 | Crystal Structure of Mnk2-D228G in complex with Staurosporine | x-ray diffraction | A | — | — |
| 2HW7 | Crystal structure of MNK2-D228G in complex with staurosporine | x-ray diffraction | A | — | — |
| 6CJ5 | Crystal Structure of Mnk2-D228G in Complex With Inhibitor | x-ray diffraction | A | ZN, F4G | 2 (best 0.68) |
| 6CJ5 | Crystal structure of MNK2-D228G in complex with inhibitor | x-ray diffraction | A | ZN, F4G | — |
| 6CJE | Crystal Structure of Mnk2-D228G in complex with Inhibitor | x-ray diffraction | A | ZN, F4A | 2 (best 0.68) |
| 6CJE | Crystal structure of MNK2-D228G in complex with inhibitor | x-ray diffraction | A | ZN, F4A | — |
| 6CJH | Co-crystal structure of MNK2 in complex with an inhibitor | x-ray diffraction | A | ZN, ET8 | 3 (best 0.65) |
| 6CJH | Co-crystal structure of MNK2 in complex with an inhibitor | x-ray diffraction | A | ZN, ET8 | — |
| 6CJW | Crystal Structure of Mnk2-D228G in Complex With Inhibitor | x-ray diffraction | A | ZN, FYV | — |
| 6CJW | Crystal structure of MNK2-D228G in complex with inhibitor | x-ray diffraction | A | ZN, FYV | — |
| 6CJY | Crystal Structure of Mnk2-D228G in complex with Inhibitor | x-ray diffraction | A | ZN, F4J | 2 (best 0.71) |
| 6CJY | Crystal structure of MNK2-D228G in complex with inhibitor | x-ray diffraction | A | ZN, F4J | — |
| 6CK3 | Co-crytsal Structure of MNK2 in Complex With an Inhibitor | x-ray diffraction | A | ZN, F67, CL | 2 (best 0.68) |
| 6CK3 | Co-crytsal structure of MNK2 in complex with an inhibitor | x-ray diffraction | A | ZN, F67, CL | — |
| 6CK6 | Crystal Structure of Mnk2-D228G in complex with Inhibitor | x-ray diffraction | A | ZN, N45 | 2 (best 0.65) |
| 6CK6 | Crystal structure of MNK2-D228G in complex with inhibitor | x-ray diffraction | A | ZN, N45 | — |
| 6CKI | Co-crystal structure of MNK2 in Complex With Inhibitor | x-ray diffraction | A | ZN, FZJ | 2 (best 0.66) |
| 6CKI | Co-crystal structure of MNK2 in complex with inhibitor | x-ray diffraction | A | ZN, FZJ | — |
| 6JLR | Crystal structure of wild type MNK2 in complex with inhibitor | x-ray diffraction | A | BV9 | 3 (best 0.77) |
| 6JLR | Crystal structure of wild type MNK2 in complex with inhibitor | x-ray diffraction | A | BV9 | — |
| 8P9B | Crystal Structure of Mnk2-D228G in complex with Tinodasertib | x-ray diffraction | A | ZN, X8K | 2 (best 0.61) |
| 8XFM | The Crystal Structure of MNK2 from Biortus. | x-ray diffraction | A | A1LU6, ZN | 2 (best 0.67) |
| Q9HBH9 | AlphaFold monomer V2.0 prediction for MAP kinase-interacting SERINE/THREONINE-protein kinase 2… | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 18 records
- BV9 · 4-[5-(1-methylpyrazol-4-yl)pyridin-3-yl]benzamide · in 2 records
- CL · Chloride ion · in 2 records
- ET8 · 3-phenyl-5-(pyridin-4-yl)-1H-indazole · in 2 records
- F4A · 4-[(9H-purin-6-yl)amino]benzamide · in 2 records
- F4G · 3-(pyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide · in 2 records
- F4J · 5-[(7H-purin-6-yl)amino]-1H-isoindol-1-one · in 2 records
- F67 · (3R)-3-methyl-5-[(pyrimidin-4-yl)amino]-2,3-dihydro-1H-isoindol-1-one · in 2 records
- FYV · 3-(pyridin-4-yl)imidazo[1,2-b]pyridazine · in 2 records
- FZJ · 3,3-dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione · in 2 records
- N45 · 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione · in 2 records
- A1LU6 · 5-(3-azanyl-1~{H}-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one · in 1 record
- X8K · 4-[6-(4-morpholin-4-ylcarbonylphenyl)imidazo[1,2-a]pyridin-3-yl]benzenecarbonitrile · in 1 record
Experiment against prediction
- 8XFM chain A against the predicted model Q9HBH9: TM-score 0.89, RMSD 1.97 Å
- 6CJW chain A against the predicted model Q9HBH9: TM-score 0.89, RMSD 2.02 Å
- 6CJW chain A against the predicted model Q9HBH9: TM-score 0.89, RMSD 2.02 Å
- 2HW7 chain A against the predicted model Q9HBH9: TM-score 0.89, RMSD 1.58 Å
- 2HW7 chain A against the predicted model Q9HBH9: TM-score 0.89, RMSD 1.58 Å
- 6CK6 chain A against the predicted model Q9HBH9: TM-score 0.88, RMSD 2.06 Å
- 6CK6 chain A against the predicted model Q9HBH9: TM-score 0.88, RMSD 2.06 Å
- 8P9B chain A against the predicted model Q9HBH9: TM-score 0.88, RMSD 1.83 Å
- 6CK3 chain A against the predicted model Q9HBH9: TM-score 0.88, RMSD 2.09 Å
- 6CK3 chain A against the predicted model Q9HBH9: TM-score 0.88, RMSD 2.09 Å
Elsewhere
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