UniProt Q9H7E2
Tudor domain-containing protein 3 (Q9H7E2)
Tudor domain-containing protein 3 (UniProt Q9H7E2): 21 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H7E2
- Protein
- Tudor domain-containing protein 3
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 5 · 0 records with a druggable one
Structures
22 records of Q9H7E2 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WJI | Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3 | solution nmr | A | — | — |
| 1WJI | Solution structure of the uba domain of human tudor domain containing protein 3 | solution nmr | A | — | — |
| 2LTO | TDRD3 complex | solution nmr | A | — | — |
| 2LTO | TDRD3 complex | solution nmr | A | — | — |
| 3PMT | Crystal structure of the Tudor domain of human Tudor domain-containing protein 3 | x-ray diffraction | A | — | — |
| 3PMT | Crystal structure of the tudor domain of human tudor domain-containing protein 3 | x-ray diffraction | A | — | — |
| 3PNW | Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB | x-ray diffraction | C, F, I, L, O, R, U, X | — | — |
| 3PNW | Crystal structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 Fab | x-ray diffraction | C, F, I, L, O, R, U, X | — | — |
| 3S6W | Crystal structure of Tudor domain of human TDRD3 | x-ray diffraction | A | — | — |
| 3S6W | Crystal structure of tudor domain of human TDRD3 | x-ray diffraction | A | — | — |
| 5GVD | Human TDRD3 DUF1767-OB domains | x-ray diffraction | A, B | PO4, MG | — |
| 5GVD | Human TDRD3 DUF1767-ob domains | x-ray diffraction | A, B | — | — |
| 5GVE | Human TOP3B-TDRD3 complex | x-ray diffraction | B | — | — |
| 5GVE | Human TOP3B-TDRD3 complex | x-ray diffraction | B | — | — |
| 5YJ8 | Identification of a small molecule inhibitor for the Tudor domain of TDRD3 | x-ray diffraction | A | 8W9, SO4 | — |
| 5YJ8 | Identification of a small molecule inhibitor for the tudor domain of TDRD3 | x-ray diffraction | A | 8W9, SO4 | — |
| 6V9T | Tudor domain of TDRD3 in complex with a small molecule | x-ray diffraction | AAA, BBB | 36X, UNX | — |
| 8JTN | Tudor domain of TDRD3 in complex with a small molecule | x-ray diffraction | A | F5W | — |
| 9C9Y | Human TOP3B-TDRD3 core complex in DNA pre-cleavage state | electron microscopy | B | — | 1 (best 0.38) |
| 9CA0 | Human TOP3B-TDRD3 core complex in DNA pre-cleavage state | electron microscopy | B | — | 2 (best 0.42) |
| 9CA1 | Human TOP3B-TDRD3 core complex in DNA religation state | electron microscopy | B | — | 1 (best 0.45) |
| Q9H7E2 | AlphaFold monomer V2.0 prediction for tudor domain-containing protein 3 (Q9H7E2) | predicted | A | — | 1 (best 0.49) |
Ligands
- 8W9 · 5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one · in 2 records
- SO4 · Sulfate ion · in 2 records
- 36X · 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine · in 1 record
- F5W · 2-propyl-2-azoniatricyclo[7.3.0.0^{3,7}]dodeca-1(9),2,7-trien-8-amine · in 1 record
- MG · Magnesium ion · in 1 record
- PO4 · Phosphate ion · in 1 record
- UNX · Unknown atom or ion · in 1 record
Experiment against prediction
- 3PNW chain F against the predicted model Q9H7E2: TM-score 0.98, RMSD 0.35 Å
- 3PNW chain F against the predicted model Q9H7E2: TM-score 0.98, RMSD 0.35 Å
- 3PMT chain A against the predicted model Q9H7E2: TM-score 0.98, RMSD 0.36 Å
- 3PMT chain A against the predicted model Q9H7E2: TM-score 0.98, RMSD 0.36 Å
- 3S6W chain A against the predicted model Q9H7E2: TM-score 0.98, RMSD 0.37 Å
- 3S6W chain A against the predicted model Q9H7E2: TM-score 0.98, RMSD 0.37 Å
- 3PNW chain L against the predicted model Q9H7E2: TM-score 0.97, RMSD 0.40 Å
- 3PNW chain L against the predicted model Q9H7E2: TM-score 0.97, RMSD 0.40 Å
- 3PNW chain X against the predicted model Q9H7E2: TM-score 0.97, RMSD 0.44 Å
- 3PNW chain X against the predicted model Q9H7E2: TM-score 0.97, RMSD 0.44 Å
Elsewhere
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