UniProt Q9H668
CST complex subunit STN1 (Q9H668)
CST complex subunit STN1 (UniProt Q9H668), EC 2.7.7.48, 3.4.22.28: 14 experimental structures and 1 predicted model on GenesisL1, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H668
- Protein
- CST complex subunit STN1
- EC
- 2.7.7.48, 3.4.22.28, 3.4.22.29, 3.6.1.15
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 40 · 6 records with a druggable one
Structures
15 records of Q9H668 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JOI | Crystal structure of the human telomeric Stn1-Ten1 complex | x-ray diffraction | A, B | — | — |
| 4JOI | Crystal structure of the human telomeric STN1-TEN1 complex | x-ray diffraction | A, B | — | — |
| 4JQF | Structure of the C-terminal domain of human telomeric Stn1 | x-ray diffraction | A | — | — |
| 4JQF | Structure of the C-terminal domain of human telomeric STN1 | x-ray diffraction | A | — | — |
| 6W6W | Cryo-EM structure of CST bound to telomeric single-stranded DNA | electron microscopy | C | — | 8 (best 0.67) |
| 6W6W | Cryo-EM structure of cst bound to telomeric single-stranded DNA | electron microscopy | C | — | — |
| 7U5C | Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | F | — | 1 (best 0.81) |
| 7U5C | Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | F | — | — |
| 8D0B | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | electron microscopy | B | — | 6 (best 0.82) |
| 8D0B | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template | electron microscopy | B | — | — |
| 8D0K | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template… | electron microscopy | B | — | 4 (best 0.75) |
| 8D0K | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template… | electron microscopy | B | — | — |
| 8SOJ | Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA | electron microscopy | B | — | 11 (best 0.80) |
| 8SOK | Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA | electron microscopy | B | — | 7 (best 0.81) |
| Q9H668 | AlphaFold monomer V2.0 prediction for cst complex subunit STN1 (Q9H668) | predicted | A | — | 3 (best 0.44) |
Experiment against prediction
- 4JQF chain A against the predicted model Q9H668: TM-score 0.99, RMSD 0.42 Å
- 4JQF chain A against the predicted model Q9H668: TM-score 0.99, RMSD 0.42 Å
- 4JOI chain A against the predicted model Q9H668: TM-score 0.96, RMSD 1.27 Å
- 4JOI chain A against the predicted model Q9H668: TM-score 0.96, RMSD 1.27 Å
- 4JOI chain B against the predicted model Q9H668: TM-score 0.94, RMSD 1.26 Å
- 4JOI chain B against the predicted model Q9H668: TM-score 0.94, RMSD 1.26 Å
- 7U5C chain F against the predicted model Q9H668: TM-score 0.85, RMSD 2.33 Å
- 7U5C chain F against the predicted model Q9H668: TM-score 0.85, RMSD 2.33 Å
- 8D0B chain B against the predicted model Q9H668: TM-score 0.57, RMSD 5.01 Å
- 8D0B chain B against the predicted model Q9H668: TM-score 0.57, RMSD 5.01 Å
Elsewhere
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