UniProt Q9H3P2
Negative elongation factor A (Q9H3P2)
Negative elongation factor A (UniProt Q9H3P2): 12 experimental structures and 1 predicted model on GenesisL1, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H3P2
- Protein
- Negative elongation factor A
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 16 · 6 records with a druggable one
Structures
13 records of Q9H3P2 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5L3X | Crystal structure of negative elongation factor subcomplex NELF-AC | x-ray diffraction | A | — | — |
| 5L3X | Crystal structure of negative elongation factor subcomplex nelf-ac | x-ray diffraction | A | — | — |
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | U | — | — |
| 7PKS | Structural basis of Integrator-mediated transcription regulation | electron microscopy | U | — | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | e | — | — |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | u | — | — |
| 8UHA | Structure of paused transcription complex Pol II-DSIF-NELF - tilted | electron microscopy | U | — | 3 (best 0.74) |
| 8UHD | Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated | electron microscopy | U | — | 3 (best 0.75) |
| 8UHG | Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated | electron microscopy | U | — | 2 (best 0.78) |
| 8UI0 | Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated | electron microscopy | U | — | 2 (best 0.78) |
| 8UIS | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | electron microscopy | U | — | 3 (best 0.78) |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | U | — | 2 (best 0.77) |
| Q9H3P2 | AlphaFold monomer V2.0 prediction for negative elongation factor a (Q9H3P2) | predicted | A | — | 1 (best 0.26) |
Experiment against prediction
- 5L3X chain A against the predicted model Q9H3P2: TM-score 0.98, RMSD 0.72 Å
- 5L3X chain A against the predicted model Q9H3P2: TM-score 0.98, RMSD 0.72 Å
- 8W8E chain U against the predicted model Q9H3P2: TM-score 0.93, RMSD 1.49 Å
- 6GML chain U against the predicted model Q9H3P2: TM-score 0.92, RMSD 1.83 Å
- 7YCX chain e against the predicted model Q9H3P2: TM-score 0.90, RMSD 1.96 Å
- 7PKS chain U against the predicted model Q9H3P2: TM-score 0.90, RMSD 1.79 Å
- 8RBX chain u against the predicted model Q9H3P2: TM-score 0.89, RMSD 1.97 Å
- 8UHA chain U against the predicted model Q9H3P2: TM-score 0.86, RMSD 1.44 Å
- 8UI0 chain U against the predicted model Q9H3P2: TM-score 0.86, RMSD 1.47 Å
- 8UHG chain U against the predicted model Q9H3P2: TM-score 0.85, RMSD 1.47 Å
Elsewhere
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