UniProt Q9H244
P2Y purinoceptor 12 (Q9H244)
P2Y purinoceptor 12 (UniProt Q9H244): 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H244
- Protein
- P2Y purinoceptor 12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 11 · 3 records with a druggable one
Structures
9 records of Q9H244 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NTJ | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | x-ray diffraction | A | — | — |
| 4NTJ | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | x-ray diffraction | A | — | — |
| 4PXZ | Crystal structure of P2Y12 receptor in complex with 2MeSADP | x-ray diffraction | A | — | — |
| 4PXZ | Crystal structure of P2Y12 receptor in complex with 2MESADP | x-ray diffraction | A | — | — |
| 4PY0 | Crystal structure of P2Y12 receptor in complex with 2MeSATP | x-ray diffraction | A | — | — |
| 4PY0 | Crystal structure of P2Y12 receptor in complex with 2MESATP | x-ray diffraction | A | — | — |
| 7PP1 | Crystal structure of the P2Y12 receptor in complex with the inverse agonist selatogrel. | x-ray diffraction | AAA | 7Y5, CLR | 1 (best 0.68) |
| 7XXI | Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi | electron microscopy | A | 6AD | 6 (best 0.83) |
| Q9H244 | AlphaFold monomer V2.0 prediction for P2Y purinoceptor 12 (Q9H244) | predicted | A | — | 4 (best 0.83) |
Ligands
Experiment against prediction
- 7XXI chain A against the predicted model Q9H244: TM-score 0.95, RMSD 1.69 Å
- 4PXZ chain A against the predicted model Q9H244: TM-score 0.70, RMSD 1.76 Å
- 4PXZ chain A against the predicted model Q9H244: TM-score 0.70, RMSD 1.76 Å
- 4PY0 chain A against the predicted model Q9H244: TM-score 0.70, RMSD 1.72 Å
- 4PY0 chain A against the predicted model Q9H244: TM-score 0.70, RMSD 1.72 Å
- 4PXZ chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.41 Å
- 4PXZ chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.41 Å
- 4PY0 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.03 Å
- 4PY0 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.03 Å
- 4NTJ chain A against the predicted model Q9H244: TM-score 0.67, RMSD 2.65 Å
Elsewhere
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