UniProt Q9H0J9
Protein mono-ADP-ribosyltransferase PARP12 (Q9H0J9)
Protein mono-ADP-ribosyltransferase PARP12 (UniProt Q9H0J9), EC 2.4.2.-: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9H0J9
- Protein
- Protein mono-ADP-ribosyltransferase PARP12
- EC
- 2.4.2.-
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 13 · 3 records with a druggable one
Structures
6 records of Q9H0J9 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2PQF | Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment in complex with an inhibitor… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2PQF | Human POLY(ADP-ribose) polymerase 12, catalytic fragment in complex with an inhibitor… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6V3W | Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with… | x-ray diffraction | A | QO4, CL | 2 (best 0.58) |
| 6V3W | Human POLY(ADP-ribose) polymerase 12, catalytic fragment with four point mutations in complex with… | x-ray diffraction | A | QO4, CL | — |
| 8XPX | The Crystal Structure of PARP12 from Biortus. | x-ray diffraction | A, B | — | 4 (best 0.72) |
| Q9H0J9 | AlphaFold monomer V2.0 prediction for protein mono-ADP- ribosyltransferase PARP12 (Q9H0J9) | predicted | A | — | 7 (best 0.78) |
Ligands
Experiment against prediction
- 8XPX chain B against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.87 Å
- 2PQF chain F against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.95 Å
- 2PQF chain F against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.95 Å
- 2PQF chain D against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.92 Å
- 2PQF chain D against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.92 Å
- 6V3W chain A against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.94 Å
- 6V3W chain A against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.94 Å
- 2PQF chain B against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.99 Å
- 2PQF chain B against the predicted model Q9H0J9: TM-score 0.98, RMSD 0.99 Å
- 8XPX chain A against the predicted model Q9H0J9: TM-score 0.97, RMSD 1.03 Å
Elsewhere
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