UniProt Q9H0H5
Rac GTPase-activating protein 1 (Q9H0H5)
Rac GTPase-activating protein 1 (UniProt Q9H0H5): 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H0H5
- Protein
- Rac GTPase-activating protein 1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 9 · 3 records with a druggable one
Structures
15 records of Q9H0H5 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OVJ | The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP. | x-ray diffraction | A | — | — |
| 2OVJ | The crystal structure of the human rac GTPase activating protein 1 (RACGAP1) mgcracgap. | x-ray diffraction | A | — | — |
| 3W6R | Crystal structure of the GAP domain of human MgcRacGAP | x-ray diffraction | A | — | — |
| 3W6R | Crystal structure of the gap domain of human mgcracgap | x-ray diffraction | A | — | — |
| 3WPQ | crystal structure of the GAP domain of MgcRacGAP(S387A) | x-ray diffraction | A, B | — | — |
| 3WPQ | Crystal structure of the gap domain of MGCRACGAP(S387A) | x-ray diffraction | A, B | — | — |
| 3WPS | crystal structure of the GAP domain of MgcRacGAP(S387D) | x-ray diffraction | A, B | — | — |
| 3WPS | Crystal structure of the gap domain of MGCRACGAP(S387D) | x-ray diffraction | A, B | — | — |
| 4B6D | Structure of the atypical C1 domain of MgcRacGAP | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4B6D | Structure of the atypical C1 domain of mgcracgap | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5C2J | Complex structure of the GAP domain of MgcRacGAP and Cdc42 | x-ray diffraction | A | GDP, AF3 | 3 (best 0.72) |
| 5C2J | Complex structure of the gap domain of mgcracgap and CDC42 | x-ray diffraction | A | — | — |
| 5C2K | Crystal structure of the fusion protein linked by RhoA and the GAP domain of MgcRacGAP | x-ray diffraction | A | MG, AF3, GDP | 2 (best 0.71) |
| 5C2K | Crystal structure of the fusion protein linked by rhoa and the gap domain of mgcracgap | x-ray diffraction | A | — | — |
| Q9H0H5 | AlphaFold monomer V2.0 prediction for rac GTPase-activating protein 1 (Q9H0H5) | predicted | A | — | 4 (best 0.72) |
Ligands
Experiment against prediction
- 3WPQ chain A against the predicted model Q9H0H5: TM-score 0.99, RMSD 0.69 Å
- 3WPQ chain A against the predicted model Q9H0H5: TM-score 0.99, RMSD 0.69 Å
- 2OVJ chain A against the predicted model Q9H0H5: TM-score 0.98, RMSD 0.98 Å
- 2OVJ chain A against the predicted model Q9H0H5: TM-score 0.98, RMSD 0.98 Å
- 3WPQ chain B against the predicted model Q9H0H5: TM-score 0.98, RMSD 0.92 Å
- 3WPQ chain B against the predicted model Q9H0H5: TM-score 0.98, RMSD 0.92 Å
- 3W6R chain A against the predicted model Q9H0H5: TM-score 0.97, RMSD 1.06 Å
- 3W6R chain A against the predicted model Q9H0H5: TM-score 0.97, RMSD 1.06 Å
- 5C2J chain A against the predicted model Q9H0H5: TM-score 0.97, RMSD 1.13 Å
- 5C2J chain A against the predicted model Q9H0H5: TM-score 0.97, RMSD 1.13 Å
Elsewhere
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