UniProt Q9GZV5

WW domain-containing transcription regulator protein 1 (Q9GZV5)

WW domain-containing transcription regulator protein 1 (UniProt Q9GZV5): 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q9GZV5
Protein: WW domain-containing transcription regulator protein 1
Experimental structures: 7
Predicted models: 1
Ligands: 4
Pockets: 2 · 0 records with a druggable one

Structures

8 records of Q9GZV5 in the MolNFT archive: 7 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6RHC	Fragment AZ-003 binding at the TAZpS89/14-3-3 sigma interface	x-ray diffraction	P	K48, MG	—
6RHC	Fragment az-003 binding at the TAZPS89/14-3-3 sigma interface	x-ray diffraction	P	K48, MG	—
6RP6	Fragment AZ-019 binding at the TAZpS89/14-3-3 sigma interface	x-ray diffraction	P	KDK	1 (best 0.32)
6RP6	Fragment az-019 binding at the TAZPS89/14-3-3 sigma interface	x-ray diffraction	P	KDK	—
6SLW	Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface	x-ray diffraction	P	L1T	—
6SLW	Fragment az-004 binding at the TAZPS89/14-3-3 sigma interface	x-ray diffraction	P	L1T	—
8R0Z	14-3-3 sigma in complex with TAZ peptide and stabilizing fragment TCF199	x-ray diffraction	P	MG	1 (best 0.32)
Q9GZV5	AlphaFold monomer V2.0 prediction for ww domain-containing transcription regulator protein 1…	predicted	A	—	—

Ligands

MG · Magnesium ion · in 3 records
K48 · 5-azanyl-4-phenyl-thiophene-2-carboximidamide · in 2 records
KDK · 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide · in 2 records
L1T · 4-methyl-5-phenyl-thiophene-2-carboximidamide · in 2 records

Experiment against prediction

6SLW chain P against the predicted model Q9GZV5: TM-score 0.31, RMSD 2.14 Å
6SLW chain P against the predicted model Q9GZV5: TM-score 0.31, RMSD 2.14 Å
6RP6 chain P against the predicted model Q9GZV5: TM-score 0.30, RMSD 1.28 Å
6RP6 chain P against the predicted model Q9GZV5: TM-score 0.30, RMSD 1.28 Å
8R0Z chain P against the predicted model Q9GZV5: TM-score 0.30, RMSD 1.72 Å
6RHC chain P against the predicted model Q9GZV5: TM-score 0.30, RMSD 2.73 Å
6RHC chain P against the predicted model Q9GZV5: TM-score 0.30, RMSD 2.73 Å

Elsewhere

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