UniProt Q9GZT4
Serine racemase (Q9GZT4)
Serine racemase (UniProt Q9GZT4), EC 4.3.1.17, 4.3.1.18: 14 experimental structures on GenesisL1, 11 ligands bound, 63 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9GZT4
- Protein
- Serine racemase
- EC
- 4.3.1.17, 4.3.1.18, 5.1.1.18
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 63 · 8 records with a druggable one
Structures
14 records of Q9GZT4 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3L6B | X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor | x-ray diffraction | A | — | — |
| 3L6B | X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor | x-ray diffraction | A | — | — |
| 3L6R | The structure of mammalian serine racemase: Evidence for conformational changes upon inhibitor… | x-ray diffraction | A | — | — |
| 3L6R | The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor… | x-ray diffraction | A | — | — |
| 5X2L | Crystal Structure of Human Serine Racemase | x-ray diffraction | A, B | PLP, MG | 2 (best 0.66) |
| 5X2L | Crystal structure of human serine racemase | x-ray diffraction | A, B | PLP, MG | — |
| 6SLH | Conformational flexibility within the small domain of human serine racemase. | x-ray diffraction | AAA, BBB, CCC, DDD | MG, NA | 10 (best 0.71) |
| 6ZSP | Human serine racemase bound to ATP and malonate. | x-ray diffraction | AAA, BBB | MG, ATP | 5 (best 0.75) |
| 6ZUJ | Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen). | x-ray diffraction | AAA, BBB, CCC, DDD | MG, CA, NA | 9 (best 0.71) |
| 7NBC | Crystal structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem… | x-ray diffraction | AAA, BBB, CCC, DDD | PLP, CA, MG, NA, BP4 | 8 (best 0.76) |
| 7NBD | Crystal structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment… | x-ray diffraction | AAA, BBB, CCC, DDD | PLP, CA, MG, JFS, NA | 9 (best 0.80) |
| 7NBG | Crystal structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment… | x-ray diffraction | AAA, BBB, CCC, DDD | PLP, NA, CA, U78, MG, OXE | 10 (best 0.72) |
| 7NBH | Crystal structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment… | x-ray diffraction | AAA, BBB, CCC, DDD | NA, CA, W0D, MG, CL | 10 (best 0.70) |
| Q9GZT4 | AlphaFold monomer V2.0 prediction for serine racemase (Q9GZT4) | — | — | — |
Ligands
- MG · Magnesium ion · in 9 records
- NA · Sodium ion · in 6 records
- CA · Calcium ion · in 5 records
- PLP · Pyridoxal-5'-phosphate · in 5 records
- ATP · Adenosine-5'-triphosphate · in 1 record
- BP4 · biphenyl-4-ylacetic acid · in 1 record
- CL · Chloride ion · in 1 record
- JFS · [4-(1H-benzimidazol-1-yl)phenyl]methanol · in 1 record
- OXE · Ortho-xylene · in 1 record
- U78 · ~{N}-[2-(2-methylphenyl)ethyl]ethanamide · in 1 record
- W0D · N-[(1H-benzimidazol-2-yl)methyl]furan-2-carboxamide · in 1 record
Elsewhere
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