UniProt Q9FEW9
12-oxophytodienoate reductase 3 (Q9FEW9)
12-oxophytodienoate reductase 3 (UniProt Q9FEW9), EC 1.3.1.42: 19 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9FEW9
- Protein
- 12-oxophytodienoate reductase 3
- EC
- 1.3.1.42
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 54 · 10 records with a druggable one
Structures
20 records of Q9FEW9 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HS6 | Crystal structure of the E291K mutant of 12-oxophytodienoate reductase 3 (OPR3) from tomato | x-ray diffraction | A, B | — | — |
| 2HS6 | Crystal structure of the E291K mutant of 12- oxophytodienoate reductase 3 (OPR3) from tomato | x-ray diffraction | A, B | — | — |
| 2HS8 | Crystal structure of the Y364F mutant of 12-oxophytodienoate reductase 3 from tomato | x-ray diffraction | A, B | — | — |
| 2HS8 | Crystal structure of the Y364F mutant of 12-oxophytodienoate reductase 3 from tomato | x-ray diffraction | A, B | — | — |
| 2HSA | Crystal structure of 12-oxophytodienoate reductase 3 (OPR3) from tomato | x-ray diffraction | B, A | — | — |
| 2HSA | Crystal structure of 12-oxophytodienoate reductase 3 (OPR3) from tomato | x-ray diffraction | B, A | — | — |
| 3HGO | Crystal structure of the F74Y/H244Y OPR3 double mutant from tomato | x-ray diffraction | A, B | — | — |
| 3HGO | Crystal structure of the F74Y/H244Y OPR3 double mutant from tomato | x-ray diffraction | A, B | — | — |
| 3HGS | Crystal structure of tomato OPR3 in complex with pHB | x-ray diffraction | A, B | — | — |
| 3HGS | Crystal structure of tomato OPR3 in complex with phb | x-ray diffraction | A, B | — | — |
| 8AUA | 12-oxophytodienoate reductase 3 (OPR3) from Solanum lycopersicum in complex with ethyl… | x-ray diffraction | A, B | FMN, L9I | 5 (best 0.80) |
| 8AUB | 12-oxophytodienoate reductase 3 (OPR3) from Solanum lycopersicum in complex with ethyl… | x-ray diffraction | A, B | FMN, O8I | 5 (best 0.79) |
| 8AUE | 12-oxophytodienoate reductase 3 (OPR3) from Solanum lycopersicum in complex with 2-methoxyethyl… | x-ray diffraction | A, B | FMN, O8R, GLY | 6 (best 0.79) |
| 8AUJ | OPR3 Y190F variant in complex with ethyl (Z)-2-(hydroxyimino)-3-oxobutanoate | x-ray diffraction | A, B | FMN, L9I | 6 (best 0.82) |
| 8QN1 | OPR3 variant - R283D | x-ray diffraction | A, C, B, D | FMN | 10 (best 0.84) |
| 8QN3 | OPR3 wildtype in complex with NADH4 | x-ray diffraction | A, B | FMN, SO4, WI6 | 5 (best 0.76) |
| 9EM2 | OPR3 wild type in its dimeric form obtained without sulfate | x-ray diffraction | B, A | FMN | 6 (best 0.76) |
| 9EM3 | OPR3 wild type in its monomeric form | x-ray diffraction | A | FMN | 2 (best 0.70) |
| 9EM4 | OPR3 variant Y364P in its dimeric form obtained with ammonium sulfate | x-ray diffraction | B, A | FMN, SO4 | 6 (best 0.71) |
| Q9FEW9 | AlphaFold monomer V2.0 prediction for 12-oxophytodienoate reductase 3 (Q9FEW9) | predicted | A | — | 3 (best 0.79) |
Ligands
- FMN · Flavin mononucleotide · in 9 records
- L9I · ethyl (2Z)-2-hydroxyimino-3-oxidanylidene-butanoate · in 2 records
- SO4 · Sulfate ion · in 2 records
- GLY · Glycine · in 1 record
- O8I · ethyl (2~{Z})-2-hydroxyimino-3-oxidanylidene-pentanoate · in 1 record
- O8R · 2-methoxyethyl (2~{Z})-2-hydroxyimino-3-oxidanylidene-butanoate · in 1 record
- WI6 · 1,4,5,6-Tetrahydronicotinamide adenine dinucleotide · in 1 record
Experiment against prediction
- 8QN3 chain B against the predicted model Q9FEW9: TM-score 1.00, RMSD 0.46 Å
- 3HGS chain B against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.50 Å
- 3HGS chain B against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.50 Å
- 9EM3 chain A against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.52 Å
- 2HS6 chain A against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.54 Å
- 2HS6 chain A against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.54 Å
- 2HS8 chain B against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.76 Å
- 2HS8 chain B against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.76 Å
- 3HGO chain B against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.77 Å
- 3HGO chain B against the predicted model Q9FEW9: TM-score 0.99, RMSD 0.77 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.