UniProt Q9BXA5
Succinate receptor 1 (Q9BXA5)
Succinate receptor 1 (UniProt Q9BXA5), EC 1.13.12.13: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BXA5
- Protein
- Succinate receptor 1
- EC
- 1.13.12.13
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 35 · 7 records with a druggable one
Structures
8 records of Q9BXA5 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JPN | Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi | electron microscopy | R | U9S | 5 (best 0.70) |
| 8JPP | Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq | electron microscopy | R | — | 3 (best 0.70) |
| 8WOG | Cryo-EM structure of SUCR1 in complex with succinate and Gi protein | electron microscopy | A | — | 6 (best 0.68) |
| 8WP1 | Cryo-EM structure of SUCR1 in complex with cis-epoxysuccinic acid and Gi proteins | electron microscopy | A | U9S | 5 (best 0.67) |
| 8YKV | Cryo-EM structure of succinate receptor SUCR1 bound to compound 31 | electron microscopy | R | A1LYV | 5 (best 0.65) |
| 8YKW | Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid | electron microscopy | R | — | 5 (best 0.72) |
| 8YKX | Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid | electron microscopy | R | MAE | 3 (best 0.64) |
| Q9BXA5 | AlphaFold monomer V2.0 prediction for succinate receptor 1 (Q9BXA5) | predicted | A | — | 3 (best 0.49) |
Ligands
Experiment against prediction
- 8JPP chain R against the predicted model Q9BXA5: TM-score 0.96, RMSD 1.49 Å
- 8YKW chain R against the predicted model Q9BXA5: TM-score 0.95, RMSD 1.48 Å
- 8YKX chain R against the predicted model Q9BXA5: TM-score 0.95, RMSD 1.47 Å
- 8JPN chain R against the predicted model Q9BXA5: TM-score 0.95, RMSD 1.51 Å
- 8WP1 chain A against the predicted model Q9BXA5: TM-score 0.95, RMSD 1.56 Å
- 8YKV chain R against the predicted model Q9BXA5: TM-score 0.95, RMSD 1.48 Å
- 8WOG chain A against the predicted model Q9BXA5: TM-score 0.95, RMSD 1.70 Å
- 8JPP chain R against the predicted model P0ABE7: TM-score 0.26, RMSD 4.30 Å
- 8JPN chain R against the predicted model P0ABE7: TM-score 0.26, RMSD 4.50 Å
- 8JPN chain R against the predicted model Q9GV45: TM-score 0.22, RMSD 6.04 Å
Elsewhere
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