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Ligand · U9S

U9S · (2R,3S)-oxirane-2,3-dicarboxylic acid

U9S, (2R,3S)-oxirane-2,3-dicarboxylic acid (C4 H4 O5, 132.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
U9S
Formula
C4 H4 O5
Class
ligand
Structures
4
PDB entries
3

Binding sites

U9S in 4 structures; the first of them:

  • 6WSI · Intact cis-2,3-epoxysuccinic acid bound to Isocitrate Lyase-1 from Mycobacterium… · U9S A504 · binds TRP93, ASP108, CYS191, GLY192, HIS193, ARG228, GLU285, ASN313 and 6 more
  • 8JPN · Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi · U9S R501 · binds LEU26, TYR30, LEU79, TYR83, ARG99, LEU102, HIS103, ASP174 and 3 more
  • 8WP1 · Cryo-EM structure of SUCR1 in complex with cis-epoxysuccinic acid and Gi proteins · U9S A401 · binds TYR30, LEU79, TYR83, ARG99, LEU102, HIS103, ASP174, PHE175 and 3 more
  • 6WSI · Intact cis-2,3-epoxysuccinic acid bound to isocitrate lyase-1 from mycobacterium… · U9S A504 · binds TRP93, ASP108, CYS191, GLY192, HIS193, ARG228, GLU285, ASN313 and 4 more

Residues it binds most

SER 8, LEU 10, ARG 10, ASP 10, HIS 10, ASN 8, CYS 8, GLU 8, GLY 8, THR 8 (residue and the binding sites it lines).

Found with

  • GLV · Glyoxylic acid
  • MG · Magnesium ion
  • GOL · Glycerol
  • PEG · Di(hydroxyethyl)ether

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